The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis
The extracellular milieu is a rich source of different stimuli and stressors. Some of them depend on the chemical–physical features of the matrix, while others may come from the ‘outer’ environment, as in the case of mechanical loading applied on the bones. In addition to these forces, a plethora of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/3/689 |
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| author | Martina Perin Giorgia Chinigò Tullio Genova Federico Mussano Luca Munaron |
| author_facet | Martina Perin Giorgia Chinigò Tullio Genova Federico Mussano Luca Munaron |
| author_sort | Martina Perin |
| collection | DOAJ |
| description | The extracellular milieu is a rich source of different stimuli and stressors. Some of them depend on the chemical–physical features of the matrix, while others may come from the ‘outer’ environment, as in the case of mechanical loading applied on the bones. In addition to these forces, a plethora of chemical signals drives cell physiology and fate, possibly leading to dysfunctions when the homeostasis is disrupted. This variety of stimuli triggers different responses among the tissues: bones represent a particular milieu in which a fragile balance between mechanical and metabolic demands should be tuned and maintained by the concerted activity of cell biomolecules located at the interface between external and internal environments. Plasma membrane ion channels can be viewed as multifunctional protein machines that act as rapid and selective dual-nature hubs, sensors, and transducers. Here we focus on some multisensory ion channels (belonging to Piezo, TRP, ASIC/EnaC, P2XR, Connexin, and Pannexin families) actually or potentially playing a significant role in bone adaptation to three main stressors, mechanical forces, oxidative stress, and acidosis, through their effects on bone cells including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. Ion channel-mediated bone remodeling occurs in physiological processes, aging, and human diseases such as osteoporosis, cancer, and traumatic events. |
| first_indexed | 2024-03-11T07:00:28Z |
| format | Article |
| id | doaj.art-576a4e0adbf047bebe402611103b96fe |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T07:00:28Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-576a4e0adbf047bebe402611103b96fe2023-11-17T09:18:22ZengMDPI AGAntioxidants2076-39212023-03-0112368910.3390/antiox12030689The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and AcidosisMartina Perin0Giorgia Chinigò1Tullio Genova2Federico Mussano3Luca Munaron4Department of Life Sciences and System Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, ItalyDepartment of Life Sciences and System Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, ItalyDepartment of Life Sciences and System Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, ItalyC.I.R. Dental School, Department of Surgical Sciences, University of Torino, Via Nizza 230, 10126 Torino, ItalyDepartment of Life Sciences and System Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, ItalyThe extracellular milieu is a rich source of different stimuli and stressors. Some of them depend on the chemical–physical features of the matrix, while others may come from the ‘outer’ environment, as in the case of mechanical loading applied on the bones. In addition to these forces, a plethora of chemical signals drives cell physiology and fate, possibly leading to dysfunctions when the homeostasis is disrupted. This variety of stimuli triggers different responses among the tissues: bones represent a particular milieu in which a fragile balance between mechanical and metabolic demands should be tuned and maintained by the concerted activity of cell biomolecules located at the interface between external and internal environments. Plasma membrane ion channels can be viewed as multifunctional protein machines that act as rapid and selective dual-nature hubs, sensors, and transducers. Here we focus on some multisensory ion channels (belonging to Piezo, TRP, ASIC/EnaC, P2XR, Connexin, and Pannexin families) actually or potentially playing a significant role in bone adaptation to three main stressors, mechanical forces, oxidative stress, and acidosis, through their effects on bone cells including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. Ion channel-mediated bone remodeling occurs in physiological processes, aging, and human diseases such as osteoporosis, cancer, and traumatic events.https://www.mdpi.com/2076-3921/12/3/689bone remodelingcalcium signalingion channelsosteogenesismechano-sensingacidosis |
| spellingShingle | Martina Perin Giorgia Chinigò Tullio Genova Federico Mussano Luca Munaron The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis Antioxidants bone remodeling calcium signaling ion channels osteogenesis mechano-sensing acidosis |
| title | The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis |
| title_full | The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis |
| title_fullStr | The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis |
| title_full_unstemmed | The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis |
| title_short | The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis |
| title_sort | impact of plasma membrane ion channels on bone remodeling in response to mechanical stress oxidative imbalance and acidosis |
| topic | bone remodeling calcium signaling ion channels osteogenesis mechano-sensing acidosis |
| url | https://www.mdpi.com/2076-3921/12/3/689 |
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