Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis
AbstractIntroduction Chronic kidney disease is related to neurodegeneration and structural changes in the brain which might lead to cognitive decline. The Fazekas scale used for assessing white matter hyperintensities (WMHs) was associated with poor cognitive performance. Therefore, this study inves...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2310142 |
| _version_ | 1827356029371809792 |
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| author | Tsai-Shan Wu Ping-Hsun Wu Hsiu-Fen Lin Wen-Ching Chen Teng-Hui Huang Ming-Yen Lin Yun-Shiuan Chuang Fan-Pei Gloria Yang Yi-Wen Chiu Jer-Ming Chang Mei-Chuan Kuo Yi-Ting Lin |
| author_facet | Tsai-Shan Wu Ping-Hsun Wu Hsiu-Fen Lin Wen-Ching Chen Teng-Hui Huang Ming-Yen Lin Yun-Shiuan Chuang Fan-Pei Gloria Yang Yi-Wen Chiu Jer-Ming Chang Mei-Chuan Kuo Yi-Ting Lin |
| author_sort | Tsai-Shan Wu |
| collection | DOAJ |
| description | AbstractIntroduction Chronic kidney disease is related to neurodegeneration and structural changes in the brain which might lead to cognitive decline. The Fazekas scale used for assessing white matter hyperintensities (WMHs) was associated with poor cognitive performance. Therefore, this study investigated the associations between the mini-mental status examination (MMSE), Montreal cognitive assessment (MoCA), cognitive abilities screening instrument (CASI), and Fazekas scale in patients under hemodialysis (HD).Methods The periventricular (PV) WMHs and deep WMHs (DWMHs) in brain magnetic resonance images of 59 patients under dialysis were graded using the Fazekas scale. Three cognition function tests were also performed, then multivariable ordinal regression and logistic regression were used to identify the associations between cognitive performance and the Fazekas scale.Results There were inverse associations between the three cognitive function tests across the Fazekas scale of PVWMHs (p = .037, .006, and .008 for MMSE, MoCA, and CASI, respectively), but the associations were attenuated in the DWMHs group. In CASI, significant differences were identified in short-term memory, mental manipulation, abstract thinking, language, spatial construction, and name fluency in the PVWMHs group. However, DWMHs were only significantly correlated with abstract thinking and short-term memory.Conclusion An inverse correlation existed between the Fazekas scale, predominantly in PVWMHs, and cognition in patients undergoing HD. The PVWMHs were associated with cognitive performance assessed by MMSE, MoCA, and CASI, as well as with subdomains of CASI such as memory, language and name fluency in patients undergoing HD. |
| first_indexed | 2024-03-08T04:52:32Z |
| format | Article |
| id | doaj.art-5774b66bcf5d44948ecc0937f55b8e35 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T04:52:32Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-5774b66bcf5d44948ecc0937f55b8e352024-02-07T22:52:48ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602024-12-0156110.1080/07853890.2024.2310142Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysisTsai-Shan Wu0Ping-Hsun Wu1Hsiu-Fen Lin2Wen-Ching Chen3Teng-Hui Huang4Ming-Yen Lin5Yun-Shiuan Chuang6Fan-Pei Gloria Yang7Yi-Wen Chiu8Jer-Ming Chang9Mei-Chuan Kuo10Yi-Ting Lin11Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanCenter for Big Data Research, Kaohsiung Medical University, Kaohsiung City, TaiwanDepartment of Foreign Languages and Literature, National Tsing Hua University, Hsinchu, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanFaculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanAbstractIntroduction Chronic kidney disease is related to neurodegeneration and structural changes in the brain which might lead to cognitive decline. The Fazekas scale used for assessing white matter hyperintensities (WMHs) was associated with poor cognitive performance. Therefore, this study investigated the associations between the mini-mental status examination (MMSE), Montreal cognitive assessment (MoCA), cognitive abilities screening instrument (CASI), and Fazekas scale in patients under hemodialysis (HD).Methods The periventricular (PV) WMHs and deep WMHs (DWMHs) in brain magnetic resonance images of 59 patients under dialysis were graded using the Fazekas scale. Three cognition function tests were also performed, then multivariable ordinal regression and logistic regression were used to identify the associations between cognitive performance and the Fazekas scale.Results There were inverse associations between the three cognitive function tests across the Fazekas scale of PVWMHs (p = .037, .006, and .008 for MMSE, MoCA, and CASI, respectively), but the associations were attenuated in the DWMHs group. In CASI, significant differences were identified in short-term memory, mental manipulation, abstract thinking, language, spatial construction, and name fluency in the PVWMHs group. However, DWMHs were only significantly correlated with abstract thinking and short-term memory.Conclusion An inverse correlation existed between the Fazekas scale, predominantly in PVWMHs, and cognition in patients undergoing HD. The PVWMHs were associated with cognitive performance assessed by MMSE, MoCA, and CASI, as well as with subdomains of CASI such as memory, language and name fluency in patients undergoing HD.https://www.tandfonline.com/doi/10.1080/07853890.2024.2310142Brain magnetic resonance imagingcognitive functionFazekas scalehemodialysis |
| spellingShingle | Tsai-Shan Wu Ping-Hsun Wu Hsiu-Fen Lin Wen-Ching Chen Teng-Hui Huang Ming-Yen Lin Yun-Shiuan Chuang Fan-Pei Gloria Yang Yi-Wen Chiu Jer-Ming Chang Mei-Chuan Kuo Yi-Ting Lin Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis Annals of Medicine Brain magnetic resonance imaging cognitive function Fazekas scale hemodialysis |
| title | Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis |
| title_full | Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis |
| title_fullStr | Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis |
| title_full_unstemmed | Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis |
| title_short | Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis |
| title_sort | cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis |
| topic | Brain magnetic resonance imaging cognitive function Fazekas scale hemodialysis |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2310142 |
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