Modeling Global Genomic Instability in Chronic Myeloid Leukemia (CML) Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs)

Modeling Global Genomic Instability in Chronic Myeloid Leukemia (CML) Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs)

Methods: We used a patient-specific induced pluripotent stem cell (iPSC) line treated with the mutagenic agent N-ethyl-N-nitrosourea (ENU). Genomic instability was validated using γ-H2AX and micronuclei assays and CGH array for genomic events. Results: An increased number of progenitors (x5-Fold), w...

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Bibliographic Details
Main Authors: Gladys Telliam, Christophe Desterke, Jusuf Imeri, Radhia M’kacher, Noufissa Oudrhiri, Estelle Balducci, Micheline Fontaine-Arnoux, Hervé Acloque, Annelise Bennaceur-Griscelli, Ali G. Turhan
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
CML
iPSC
genomic instability
Online Access:https://www.mdpi.com/2072-6694/15/9/2594

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