Causality between COVID‐19 and female reproductive function: A Mendelian randomization study
Abstract Coronavirus disease 2019 (COVID‐19) has experienced a global pandemic, and currently, the emergence of its variants has posed challenges in terms of prevention and treatment. Nonetheless, the effect of COVID‐19 infection on female reproductive function is unclear. This study aimed to system...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | MedComm – Future Medicine |
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| Online Access: | https://doi.org/10.1002/mef2.55 |
| _version_ | 1797673986856845312 |
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| author | Bowen Zhang Jixue Xu Junzhi Liang Mingjun Hao Yuexin Yu Jingzan Wei Yuanyuan Fang Zhijing Na Da Li |
| author_facet | Bowen Zhang Jixue Xu Junzhi Liang Mingjun Hao Yuexin Yu Jingzan Wei Yuanyuan Fang Zhijing Na Da Li |
| author_sort | Bowen Zhang |
| collection | DOAJ |
| description | Abstract Coronavirus disease 2019 (COVID‐19) has experienced a global pandemic, and currently, the emergence of its variants has posed challenges in terms of prevention and treatment. Nonetheless, the effect of COVID‐19 infection on female reproductive function is unclear. This study aimed to systematically evaluate for the first time the causal effect of COVID‐19 on female reproductive function. Genetic correlations were assessed using linkage disequilibrium score regression. Mendelian randomization (MR) analysis was performed using summary statistics of two variables, including COVID‐19 severity and eight female reproductive traits. The three degrees of severity had genetically significant associations with sex hormone‐binding globulin (SHBG) concentrations (rg = –0.153, p = 0.004; rg = –0.187, p < 0.001; rg = –0.180, p = 0.003). Additionally, MR showed that SHBG (β = –0.020, p = 0.040) and total testosterone levels (β = –0.061, p = 0.009) followed a decreasing trend, as the COVID‐19 infection higher. No significant genetic association was found between COVID‐19 infection and total estradiol concentrations, menstruation, and female infertility. Simultaneously, MR found no causal relationships between COVID‐19 infection and total estradiol concentrations, menstruation, and female infertility (all p > 0.05). In conclusion, COVID‐19 was causally associated with lower SHBG and total testosterone concentrations, offering invaluable insights that will help guide clinical decision‐making. |
| first_indexed | 2024-03-11T21:52:32Z |
| format | Article |
| id | doaj.art-5775bae27d764f8d97250279a21a0da3 |
| institution | Directory Open Access Journal |
| issn | 2769-6456 |
| language | English |
| last_indexed | 2024-03-11T21:52:32Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Future Medicine |
| spelling | doaj.art-5775bae27d764f8d97250279a21a0da32023-09-26T07:20:27ZengWileyMedComm – Future Medicine2769-64562023-06-0123n/an/a10.1002/mef2.55Causality between COVID‐19 and female reproductive function: A Mendelian randomization studyBowen Zhang0Jixue Xu1Junzhi Liang2Mingjun Hao3Yuexin Yu4Jingzan Wei5Yuanyuan Fang6Zhijing Na7Da Li8Department of Obstetrics and Gynecology, Center of Reproductive Medicine Shengjing Hospital of China Medical University Shenyang ChinaThe First Clinical College China Medical University Shenyang ChinaDepartment of Obstetrics and Gynecology, Center of Reproductive Medicine Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Obstetrics and Gynecology, Center of Reproductive Medicine Shengjing Hospital of China Medical University Shenyang ChinaReproductive Medicine Center General Hospital of Northern Theater Command Shenyang ChinaDepartment of Obstetrics and Gynecology, Center of Reproductive Medicine Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Obstetrics and Gynecology, Center of Reproductive Medicine Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Obstetrics and Gynecology, Center of Reproductive Medicine Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Obstetrics and Gynecology, Center of Reproductive Medicine Shengjing Hospital of China Medical University Shenyang ChinaAbstract Coronavirus disease 2019 (COVID‐19) has experienced a global pandemic, and currently, the emergence of its variants has posed challenges in terms of prevention and treatment. Nonetheless, the effect of COVID‐19 infection on female reproductive function is unclear. This study aimed to systematically evaluate for the first time the causal effect of COVID‐19 on female reproductive function. Genetic correlations were assessed using linkage disequilibrium score regression. Mendelian randomization (MR) analysis was performed using summary statistics of two variables, including COVID‐19 severity and eight female reproductive traits. The three degrees of severity had genetically significant associations with sex hormone‐binding globulin (SHBG) concentrations (rg = –0.153, p = 0.004; rg = –0.187, p < 0.001; rg = –0.180, p = 0.003). Additionally, MR showed that SHBG (β = –0.020, p = 0.040) and total testosterone levels (β = –0.061, p = 0.009) followed a decreasing trend, as the COVID‐19 infection higher. No significant genetic association was found between COVID‐19 infection and total estradiol concentrations, menstruation, and female infertility. Simultaneously, MR found no causal relationships between COVID‐19 infection and total estradiol concentrations, menstruation, and female infertility (all p > 0.05). In conclusion, COVID‐19 was causally associated with lower SHBG and total testosterone concentrations, offering invaluable insights that will help guide clinical decision‐making.https://doi.org/10.1002/mef2.55causalityCOVID‐19female reproductive functionlinkage disequilibrium score regressionMendelian randomization |
| spellingShingle | Bowen Zhang Jixue Xu Junzhi Liang Mingjun Hao Yuexin Yu Jingzan Wei Yuanyuan Fang Zhijing Na Da Li Causality between COVID‐19 and female reproductive function: A Mendelian randomization study MedComm – Future Medicine causality COVID‐19 female reproductive function linkage disequilibrium score regression Mendelian randomization |
| title | Causality between COVID‐19 and female reproductive function: A Mendelian randomization study |
| title_full | Causality between COVID‐19 and female reproductive function: A Mendelian randomization study |
| title_fullStr | Causality between COVID‐19 and female reproductive function: A Mendelian randomization study |
| title_full_unstemmed | Causality between COVID‐19 and female reproductive function: A Mendelian randomization study |
| title_short | Causality between COVID‐19 and female reproductive function: A Mendelian randomization study |
| title_sort | causality between covid 19 and female reproductive function a mendelian randomization study |
| topic | causality COVID‐19 female reproductive function linkage disequilibrium score regression Mendelian randomization |
| url | https://doi.org/10.1002/mef2.55 |
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