Low abundance of insulin-induced gene 1 contributes to SREBP-1c processing and hepatic steatosis in dairy cows with severe fatty liver

Low abundance of insulin-induced gene 1 contributes to SREBP-1c processing and hepatic steatosis in dairy cows with severe fatty liver

ABSTRACT: Fatty liver is a major metabolic disorder of high-producing dairy cows during the transition period. In nonruminants, it is well established that insulin-induced gene 1 (INSIG1) plays a crucial role in regulating hepatic lipogenesis by controlling the anchoring of sterol regulatory element...

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Bibliographic Details
Main Authors: Yiwei Zhu, Lin Lei, Xinghui Wang, Qianming Jiang, Juan J. Loor, Fanrong Kong, Linfang Chen, Jinxia Li, Chenchen Zhao, Menglin Liu, Guowen Liu, Xinwei Li
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Journal of Dairy Science
Subjects:
fatty liver
insulin-induced gene 1
sterol regulatory element-binding protein 1c
SREBP cleavage-activating protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022030223003235

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