Co(II), Ni(II), Cu(II), and Zn(II) complexes with Benzothiazole Schiff base ligand: Preparation, Spectral Characterization, DNA Binding, and In Vitro Cytotoxic Activities
2-((E)-(6-ethoxybenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol (2-EBTMCP) of Schiff base (HL) which would be produced from 6-ethoxy-2-amino benzothiazole and 5-Chloro-2-hydroxybenzaldehyde was prepared and characterised using 1H NMR, Infrared, ESI-mass spectra, elemental analysis, SEM, EDX and pow...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623001078 |
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| author | Kamble Gopichand Varukolu Mahipal N. Nageswara Rao Abdul Majeed Ganai P. Venkateswar Rao |
| author_facet | Kamble Gopichand Varukolu Mahipal N. Nageswara Rao Abdul Majeed Ganai P. Venkateswar Rao |
| author_sort | Kamble Gopichand |
| collection | DOAJ |
| description | 2-((E)-(6-ethoxybenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol (2-EBTMCP) of Schiff base (HL) which would be produced from 6-ethoxy-2-amino benzothiazole and 5-Chloro-2-hydroxybenzaldehyde was prepared and characterised using 1H NMR, Infrared, ESI-mass spectra, elemental analysis, SEM, EDX and powder XRD spectroscopic methods. Its complexes with Ni(II), Co(II), Zn(II) and Cu(III) were made, isolated as solid compounds, and identified by various spectroscopic methods. The research of metal complexes here includes the intercalative form of DNA binding studies with CT (Calf thymus) DNA. The UV–Vis electron absorption spectroscopy approach has been used to explore the DNA-binding capabilities of transition metal complexes. Additionally, a MTT assay was performed to investigate their in vitro cytotoxic potential. |
| first_indexed | 2024-03-13T04:13:28Z |
| format | Article |
| id | doaj.art-57780b9fbb5a4ec5abf5c2dc12fdaa8e |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-13T04:13:28Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-57780b9fbb5a4ec5abf5c2dc12fdaa8e2023-06-21T06:52:20ZengElsevierResults in Chemistry2211-71562023-01-015100868Co(II), Ni(II), Cu(II), and Zn(II) complexes with Benzothiazole Schiff base ligand: Preparation, Spectral Characterization, DNA Binding, and In Vitro Cytotoxic ActivitiesKamble Gopichand0Varukolu Mahipal1N. Nageswara Rao2Abdul Majeed Ganai3P. Venkateswar Rao4Department of Chemistry, Osmania University, Hyderabad, Telangana, IndiaDepartment of Chemistry, Osmania University, Hyderabad, Telangana, IndiaDepartment of Chemistry, Osmania University, Hyderabad, Telangana, IndiaDepartment of Chemistry, Osmania University, Hyderabad, Telangana, IndiaCorresponding author.; Department of Chemistry, Osmania University, Hyderabad, Telangana, India2-((E)-(6-ethoxybenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol (2-EBTMCP) of Schiff base (HL) which would be produced from 6-ethoxy-2-amino benzothiazole and 5-Chloro-2-hydroxybenzaldehyde was prepared and characterised using 1H NMR, Infrared, ESI-mass spectra, elemental analysis, SEM, EDX and powder XRD spectroscopic methods. Its complexes with Ni(II), Co(II), Zn(II) and Cu(III) were made, isolated as solid compounds, and identified by various spectroscopic methods. The research of metal complexes here includes the intercalative form of DNA binding studies with CT (Calf thymus) DNA. The UV–Vis electron absorption spectroscopy approach has been used to explore the DNA-binding capabilities of transition metal complexes. Additionally, a MTT assay was performed to investigate their in vitro cytotoxic potential.http://www.sciencedirect.com/science/article/pii/S2211715623001078Schiff baseMetal complexesDNA bindingCytotoxicity potential |
| spellingShingle | Kamble Gopichand Varukolu Mahipal N. Nageswara Rao Abdul Majeed Ganai P. Venkateswar Rao Co(II), Ni(II), Cu(II), and Zn(II) complexes with Benzothiazole Schiff base ligand: Preparation, Spectral Characterization, DNA Binding, and In Vitro Cytotoxic Activities Results in Chemistry Schiff base Metal complexes DNA binding Cytotoxicity potential |
| title | Co(II), Ni(II), Cu(II), and Zn(II) complexes with Benzothiazole Schiff base ligand: Preparation, Spectral Characterization, DNA Binding, and In Vitro Cytotoxic Activities |
| title_full | Co(II), Ni(II), Cu(II), and Zn(II) complexes with Benzothiazole Schiff base ligand: Preparation, Spectral Characterization, DNA Binding, and In Vitro Cytotoxic Activities |
| title_fullStr | Co(II), Ni(II), Cu(II), and Zn(II) complexes with Benzothiazole Schiff base ligand: Preparation, Spectral Characterization, DNA Binding, and In Vitro Cytotoxic Activities |
| title_full_unstemmed | Co(II), Ni(II), Cu(II), and Zn(II) complexes with Benzothiazole Schiff base ligand: Preparation, Spectral Characterization, DNA Binding, and In Vitro Cytotoxic Activities |
| title_short | Co(II), Ni(II), Cu(II), and Zn(II) complexes with Benzothiazole Schiff base ligand: Preparation, Spectral Characterization, DNA Binding, and In Vitro Cytotoxic Activities |
| title_sort | co ii ni ii cu ii and zn ii complexes with benzothiazole schiff base ligand preparation spectral characterization dna binding and in vitro cytotoxic activities |
| topic | Schiff base Metal complexes DNA binding Cytotoxicity potential |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623001078 |
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