Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease
Low back pain is critical health, social, and economic issue in modern societies. This disease is often associated with intervertebral disc degeneration; however, contemporary treatments are unable to target this underlying pathology to alleviate the pain symptoms. Cell therapy offers a promising no...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/58/2/267 |
| _version_ | 1797478263479599104 |
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| author | Daisuke Sakai Jordy Schol Masahiko Watanabe |
| author_facet | Daisuke Sakai Jordy Schol Masahiko Watanabe |
| author_sort | Daisuke Sakai |
| collection | DOAJ |
| description | Low back pain is critical health, social, and economic issue in modern societies. This disease is often associated with intervertebral disc degeneration; however, contemporary treatments are unable to target this underlying pathology to alleviate the pain symptoms. Cell therapy offers a promising novel therapeutic that, in theory, should be able to reduce low back pain through mitigating the degenerative disc environment. With the clinical development of cell therapeutics ongoing, this review aims to summarize reporting on the different clinical trials and assess the different regenerative strategies being undertaken to collectively obtain an impression on the potential safety and effectiveness of cell therapeutics against intervertebral disc-related diseases. |
| first_indexed | 2024-03-09T21:29:28Z |
| format | Article |
| id | doaj.art-57783abcbee04ff09f46ba50c72ea6a5 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T21:29:28Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-57783abcbee04ff09f46ba50c72ea6a52023-11-23T21:00:41ZengMDPI AGMedicina1010-660X1648-91442022-02-0158226710.3390/medicina58020267Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc DiseaseDaisuke Sakai0Jordy Schol1Masahiko Watanabe2Department of Orthopaedic Surgery, Surgical Science, School of Medicine, Tokai University, Isehara 259-1193, JapanDepartment of Orthopaedic Surgery, Surgical Science, School of Medicine, Tokai University, Isehara 259-1193, JapanDepartment of Orthopaedic Surgery, Surgical Science, School of Medicine, Tokai University, Isehara 259-1193, JapanLow back pain is critical health, social, and economic issue in modern societies. This disease is often associated with intervertebral disc degeneration; however, contemporary treatments are unable to target this underlying pathology to alleviate the pain symptoms. Cell therapy offers a promising novel therapeutic that, in theory, should be able to reduce low back pain through mitigating the degenerative disc environment. With the clinical development of cell therapeutics ongoing, this review aims to summarize reporting on the different clinical trials and assess the different regenerative strategies being undertaken to collectively obtain an impression on the potential safety and effectiveness of cell therapeutics against intervertebral disc-related diseases.https://www.mdpi.com/1648-9144/58/2/267cell therapystem cellsintervertebral discdegenerationspinelow back pain |
| spellingShingle | Daisuke Sakai Jordy Schol Masahiko Watanabe Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease Medicina cell therapy stem cells intervertebral disc degeneration spine low back pain |
| title | Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease |
| title_full | Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease |
| title_fullStr | Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease |
| title_full_unstemmed | Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease |
| title_short | Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease |
| title_sort | clinical development of regenerative medicine targeted for intervertebral disc disease |
| topic | cell therapy stem cells intervertebral disc degeneration spine low back pain |
| url | https://www.mdpi.com/1648-9144/58/2/267 |
| work_keys_str_mv | AT daisukesakai clinicaldevelopmentofregenerativemedicinetargetedforintervertebraldiscdisease AT jordyschol clinicaldevelopmentofregenerativemedicinetargetedforintervertebraldiscdisease AT masahikowatanabe clinicaldevelopmentofregenerativemedicinetargetedforintervertebraldiscdisease |