Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling

Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling

Abstract The voltage-gated K+ channel plays a key role in atrial excitability, conducting the ultra-rapid rectifier K+ current (IKur) and contributing to the repolarization of the atrial action potential. In this study, we examine its regulation by hydrogen sulfide (H2S) in HL-1 cardiomyocytes and i...

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Bibliographic Details
Main Authors:	Moza M. Al-Owais, Nishani T. Hettiarachchi, Mark L. Dallas, Jason L. Scragg, Jonathan D. Lippiat, Arun V. Holden, Derek S. Steele, Chris Peers
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-06-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-023-05016-5

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