Metformin Inhibits ROS Production by Human M2 Macrophages via the Activation of AMPK

Metformin Inhibits ROS Production by Human M2 Macrophages via the Activation of AMPK

Metformin (1,1-dimethylbiguanide hydrochloride) is the most commonly used drug to treat type II diabetic patients. It is believed that this drug has several other beneficial effects, such as anti-inflammatory and anticancer effects. Here, we wanted to evaluate the effect of metformin on the producti...

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Bibliographic Details
Main Authors: Rana M. Nassif, Elias Chalhoub, Pia Chedid, Margarita Hurtado-Nedelec, Elia Raya, Pham My-Chan Dang, Jean-Claude Marie, Jamel El-Benna
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomedicines
Subjects:
metformin
macrophage
inflammation
ROS
NADPH oxidase
NOX2
Online Access:https://www.mdpi.com/2227-9059/10/2/319

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