Antitumor Research on Artemisinin and Its Bioactive Derivatives
Abstract Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficien...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-04-01
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| Series: | Natural Products and Bioprospecting |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13659-018-0162-1 |
| _version_ | 1828874212578689024 |
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| author | Yunqin Zhang Guowei Xu Shuqun Zhang Dong Wang P. Saravana Prabha Zhili Zuo |
| author_facet | Yunqin Zhang Guowei Xu Shuqun Zhang Dong Wang P. Saravana Prabha Zhili Zuo |
| author_sort | Yunqin Zhang |
| collection | DOAJ |
| description | Abstract Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents. Graphical Abstract |
| first_indexed | 2024-12-13T07:32:42Z |
| format | Article |
| id | doaj.art-577c69f941fa465a95691d6eb94e5e8c |
| institution | Directory Open Access Journal |
| issn | 2192-2195 2192-2209 |
| language | English |
| last_indexed | 2024-12-13T07:32:42Z |
| publishDate | 2018-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj.art-577c69f941fa465a95691d6eb94e5e8c2022-12-21T23:55:09ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092018-04-018430331910.1007/s13659-018-0162-1Antitumor Research on Artemisinin and Its Bioactive DerivativesYunqin Zhang0Guowei Xu1Shuqun Zhang2Dong Wang3P. Saravana Prabha4Zhili Zuo5State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesAbstract Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents. Graphical Abstracthttp://link.springer.com/article/10.1007/s13659-018-0162-1ArtemisininArtemisinin derivativesAntitumorActivityMechanism |
| spellingShingle | Yunqin Zhang Guowei Xu Shuqun Zhang Dong Wang P. Saravana Prabha Zhili Zuo Antitumor Research on Artemisinin and Its Bioactive Derivatives Natural Products and Bioprospecting Artemisinin Artemisinin derivatives Antitumor Activity Mechanism |
| title | Antitumor Research on Artemisinin and Its Bioactive Derivatives |
| title_full | Antitumor Research on Artemisinin and Its Bioactive Derivatives |
| title_fullStr | Antitumor Research on Artemisinin and Its Bioactive Derivatives |
| title_full_unstemmed | Antitumor Research on Artemisinin and Its Bioactive Derivatives |
| title_short | Antitumor Research on Artemisinin and Its Bioactive Derivatives |
| title_sort | antitumor research on artemisinin and its bioactive derivatives |
| topic | Artemisinin Artemisinin derivatives Antitumor Activity Mechanism |
| url | http://link.springer.com/article/10.1007/s13659-018-0162-1 |
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