Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas

Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas

Abstract The blood–brain barrier (BBB) plays important roles in brain tumor pathogenesis and treatment response, yet our understanding of its function and heterogeneity within or across brain tumor types remains poorly characterized. Here we analyze the neurovascular unit (NVU) of pediatric high-gra...

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Bibliographic Details
Main Authors: Xin Wei, Michaël H. Meel, Marjolein Breur, Marianna Bugiani, Esther Hulleman, Timothy N. Phoenix
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Acta Neuropathologica Communications
Subjects:
Pediatric high-grade glioma
Diffuse midline glioma
Blood brain barrier
Endothelial cells
Neurovascular unit
Diffuse intrinsic pontine glioma
Online Access:https://doi.org/10.1186/s40478-021-01243-1

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