Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention
Acute thrombosis can be induced in rabbits by a triggering protocol using Russell's viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
1997-03-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000300017 |
| _version_ | 1811309051792850944 |
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| author | P.D. Picon S.C. Gonçalves M.V. Wainstein A.F. Costa C.V. Mengarda R.P. Machado G.L. Berlim M. Edelweiss M.I. Edelweiss J.P. Ribeiro |
| author_facet | P.D. Picon S.C. Gonçalves M.V. Wainstein A.F. Costa C.V. Mengarda R.P. Machado G.L. Berlim M. Edelweiss M.I. Edelweiss J.P. Ribeiro |
| author_sort | P.D. Picon |
| collection | DOAJ |
| description | Acute thrombosis can be induced in rabbits by a triggering protocol using Russell's viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80%) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P<0.01). Thus, this model, using balloon desendothelization without dietary manipulation, induces arterial atherosclerosis and thrombosis and may provide possibilities to test new therapeutic approaches |
| first_indexed | 2024-04-13T09:35:33Z |
| format | Article |
| id | doaj.art-577d3cff2c15434398ad66f423eca9f1 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-13T09:35:33Z |
| publishDate | 1997-03-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-577d3cff2c15434398ad66f423eca9f12022-12-22T02:52:07ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X1997-03-0130341510.1590/S0100-879X1997000300017Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary interventionP.D. PiconS.C. GonçalvesM.V. WainsteinA.F. CostaC.V. MengardaR.P. MachadoG.L. BerlimM. EdelweissM.I. EdelweissJ.P. RibeiroAcute thrombosis can be induced in rabbits by a triggering protocol using Russell's viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80%) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P<0.01). Thus, this model, using balloon desendothelization without dietary manipulation, induces arterial atherosclerosis and thrombosis and may provide possibilities to test new therapeutic approacheshttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000300017endotheliumhistamineRussell's viper venomcoronary artery disease |
| spellingShingle | P.D. Picon S.C. Gonçalves M.V. Wainstein A.F. Costa C.V. Mengarda R.P. Machado G.L. Berlim M. Edelweiss M.I. Edelweiss J.P. Ribeiro Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention Brazilian Journal of Medical and Biological Research endothelium histamine Russell's viper venom coronary artery disease |
| title | Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention |
| title_full | Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention |
| title_fullStr | Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention |
| title_full_unstemmed | Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention |
| title_short | Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention |
| title_sort | atherosclerosis and acute arterial thrombosis in rabbits a model using balloon desendothelization without dietary intervention |
| topic | endothelium histamine Russell's viper venom coronary artery disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000300017 |
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