Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people
Yanlu Xin,1 Yunyang Wang,1 Jingwei Chi,2 Xvhua Zhu,3 Hui Zhao,4 Shihua Zhao,1,2 Yangang Wang1 1Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China; 2Laboratory of Thyroid Disease, Affiliated Hospital of Qingdao University, Qingdao, China; 3Department...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-01-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/elevated-free-fatty-acid-level-is-associated-with-insulin-resistant-st-peer-reviewed-article-DMSO |
| _version_ | 1811173720547393536 |
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| author | Xin YL Wang Y Chi J Zhu X Zhao H Zhao S Wang Y |
| author_facet | Xin YL Wang Y Chi J Zhu X Zhao H Zhao S Wang Y |
| author_sort | Xin YL |
| collection | DOAJ |
| description | Yanlu Xin,1 Yunyang Wang,1 Jingwei Chi,2 Xvhua Zhu,3 Hui Zhao,4 Shihua Zhao,1,2 Yangang Wang1 1Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China; 2Laboratory of Thyroid Disease, Affiliated Hospital of Qingdao University, Qingdao, China; 3Department of Endocrinology and Metabolism, Second People’s Hospital of Qingdao West Coast, Qingdao, China; 4Department of Endocrinology and Metabolism, Hiser Medical Center of Qingdao, Qingdao, China Background: Free fatty acids (FFAs) are associated with insulin secretion and insulin resistance. However, the associations among FFAs, obesity, and progression from a normal to a prediabetic state are unclear. Methods: Nondiabetic subjects (5,952) were divided in two groups according to their body mass index (BMI): obese subjects (BMI ≥24 kg/m2) and nonobese subjects (BMI <24 kg/m2). Clinical and multiple glucolipid metabolism data were collected. The homeostasis model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β) was used. HbA1c level between 5.7% and 6.4% was considered prediabetic. Nonparametric tests, one-way ANOVA, and linear correlation analysis were performed. R and SPSS 23.0 software programs were used to analyze the results. Results: A U-shaped relationship between FFAs and HOMA-IR was observed. After adjusting for potential confounders, the turning points of FFA levels in the curves were 0.54 mmol/L in the nonobese group and 0.61 mmol/L in the obese group. HOMA-IR levels decreased with increasing FFA concentrations before the turning points (regression coefficient [β]= – 0.9, P=0.0111, for the nonobese group; β=0.2, P=0.5094, for the obese group) and then increased (β=0.9, P=0.0069, for the nonobese group; β=1.5, P=0.0263 for the obese group) after the points. Additionally, our study also identified that FFAs were associated with the prediabetes status in obese individuals. Conclusion: FFA levels were associated with insulin resistance in nondiabetic subjects, and HOMA-IR in nonobese individuals was more sensitive to FFA changes. Monitoring and controlling plasma FFA levels in obese subjects is significant in decreasing insulin resistance and preventing diabetes. Keywords: FFA, insulin resistance, T2DM, obesity, HOMA-IR |
| first_indexed | 2024-04-10T17:51:46Z |
| format | Article |
| id | doaj.art-577e23c5e54e484b8d245dcee2143599 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T17:51:46Z |
| publishDate | 2019-01-01 |
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| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-577e23c5e54e484b8d245dcee21435992023-02-02T20:33:15ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072019-01-01Volume 1213914743610Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese peopleXin YLWang YChi JZhu XZhao HZhao SWang YYanlu Xin,1 Yunyang Wang,1 Jingwei Chi,2 Xvhua Zhu,3 Hui Zhao,4 Shihua Zhao,1,2 Yangang Wang1 1Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China; 2Laboratory of Thyroid Disease, Affiliated Hospital of Qingdao University, Qingdao, China; 3Department of Endocrinology and Metabolism, Second People’s Hospital of Qingdao West Coast, Qingdao, China; 4Department of Endocrinology and Metabolism, Hiser Medical Center of Qingdao, Qingdao, China Background: Free fatty acids (FFAs) are associated with insulin secretion and insulin resistance. However, the associations among FFAs, obesity, and progression from a normal to a prediabetic state are unclear. Methods: Nondiabetic subjects (5,952) were divided in two groups according to their body mass index (BMI): obese subjects (BMI ≥24 kg/m2) and nonobese subjects (BMI <24 kg/m2). Clinical and multiple glucolipid metabolism data were collected. The homeostasis model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β) was used. HbA1c level between 5.7% and 6.4% was considered prediabetic. Nonparametric tests, one-way ANOVA, and linear correlation analysis were performed. R and SPSS 23.0 software programs were used to analyze the results. Results: A U-shaped relationship between FFAs and HOMA-IR was observed. After adjusting for potential confounders, the turning points of FFA levels in the curves were 0.54 mmol/L in the nonobese group and 0.61 mmol/L in the obese group. HOMA-IR levels decreased with increasing FFA concentrations before the turning points (regression coefficient [β]= – 0.9, P=0.0111, for the nonobese group; β=0.2, P=0.5094, for the obese group) and then increased (β=0.9, P=0.0069, for the nonobese group; β=1.5, P=0.0263 for the obese group) after the points. Additionally, our study also identified that FFAs were associated with the prediabetes status in obese individuals. Conclusion: FFA levels were associated with insulin resistance in nondiabetic subjects, and HOMA-IR in nonobese individuals was more sensitive to FFA changes. Monitoring and controlling plasma FFA levels in obese subjects is significant in decreasing insulin resistance and preventing diabetes. Keywords: FFA, insulin resistance, T2DM, obesity, HOMA-IRhttps://www.dovepress.com/elevated-free-fatty-acid-level-is-associated-with-insulin-resistant-st-peer-reviewed-article-DMSOFFAInsulin resistanceT2DMObesityHOMA-IR |
| spellingShingle | Xin YL Wang Y Chi J Zhu X Zhao H Zhao S Wang Y Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people Diabetes, Metabolic Syndrome and Obesity FFA Insulin resistance T2DM Obesity HOMA-IR |
| title | Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people |
| title_full | Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people |
| title_fullStr | Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people |
| title_full_unstemmed | Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people |
| title_short | Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people |
| title_sort | elevated free fatty acid level is associated with insulin resistant state in nondiabetic chinese people |
| topic | FFA Insulin resistance T2DM Obesity HOMA-IR |
| url | https://www.dovepress.com/elevated-free-fatty-acid-level-is-associated-with-insulin-resistant-st-peer-reviewed-article-DMSO |
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