The Hippo–YAP Signaling as Guardian in the Pool of Intestinal Stem Cells
Despite endogenous insults such as mechanical stress and danger signals derived from the microbiome, the intestine can maintain its homeostatic condition through continuous self-renewal of the crypt–villus axis. This extraordinarily rapid turnover of intestinal epithelium, known to be 3 to 5 days, c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/12/560 |
| _version_ | 1797546025220571136 |
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| author | Yoojin Seo So-Yeon Park Hyung-Sik Kim Jeong-Seok Nam |
| author_facet | Yoojin Seo So-Yeon Park Hyung-Sik Kim Jeong-Seok Nam |
| author_sort | Yoojin Seo |
| collection | DOAJ |
| description | Despite endogenous insults such as mechanical stress and danger signals derived from the microbiome, the intestine can maintain its homeostatic condition through continuous self-renewal of the crypt–villus axis. This extraordinarily rapid turnover of intestinal epithelium, known to be 3 to 5 days, can be achieved by dynamic regulation of intestinal stem cells (ISCs). The crypt base-located leucine-rich repeat-containing G-protein-coupled receptor 5-positive (Lgr5<sup>+</sup>) ISCs maintain intestinal integrity in the steady state. Under severe damage leading to the loss of conventional ISCs, quiescent stem cells and even differentiated cells can be reactivated into stem-cell-like cells with multi-potency and contribute to the reconstruction of the intestinal epithelium. This process requires fine-tuning of the various signaling pathways, including the Hippo–YAP system. In this review, we summarize recent advances in understanding the correlation between Hippo–YAP signaling and intestinal homeostasis, repair, and tumorigenesis, focusing specifically on ISC regulation. |
| first_indexed | 2024-03-10T14:24:13Z |
| format | Article |
| id | doaj.art-5780687de6aa45f5aaaf2f67aeb01cd4 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T14:24:13Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5780687de6aa45f5aaaf2f67aeb01cd42023-11-20T23:08:56ZengMDPI AGBiomedicines2227-90592020-12-0181256010.3390/biomedicines8120560The Hippo–YAP Signaling as Guardian in the Pool of Intestinal Stem CellsYoojin Seo0So-Yeon Park1Hyung-Sik Kim2Jeong-Seok Nam3Department of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, KoreaSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaDepartment of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, KoreaSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaDespite endogenous insults such as mechanical stress and danger signals derived from the microbiome, the intestine can maintain its homeostatic condition through continuous self-renewal of the crypt–villus axis. This extraordinarily rapid turnover of intestinal epithelium, known to be 3 to 5 days, can be achieved by dynamic regulation of intestinal stem cells (ISCs). The crypt base-located leucine-rich repeat-containing G-protein-coupled receptor 5-positive (Lgr5<sup>+</sup>) ISCs maintain intestinal integrity in the steady state. Under severe damage leading to the loss of conventional ISCs, quiescent stem cells and even differentiated cells can be reactivated into stem-cell-like cells with multi-potency and contribute to the reconstruction of the intestinal epithelium. This process requires fine-tuning of the various signaling pathways, including the Hippo–YAP system. In this review, we summarize recent advances in understanding the correlation between Hippo–YAP signaling and intestinal homeostasis, repair, and tumorigenesis, focusing specifically on ISC regulation.https://www.mdpi.com/2227-9059/8/12/560intestineintestinal stem cellsHippoYAPhomeostasisregeneration |
| spellingShingle | Yoojin Seo So-Yeon Park Hyung-Sik Kim Jeong-Seok Nam The Hippo–YAP Signaling as Guardian in the Pool of Intestinal Stem Cells Biomedicines intestine intestinal stem cells Hippo YAP homeostasis regeneration |
| title | The Hippo–YAP Signaling as Guardian in the Pool of Intestinal Stem Cells |
| title_full | The Hippo–YAP Signaling as Guardian in the Pool of Intestinal Stem Cells |
| title_fullStr | The Hippo–YAP Signaling as Guardian in the Pool of Intestinal Stem Cells |
| title_full_unstemmed | The Hippo–YAP Signaling as Guardian in the Pool of Intestinal Stem Cells |
| title_short | The Hippo–YAP Signaling as Guardian in the Pool of Intestinal Stem Cells |
| title_sort | hippo yap signaling as guardian in the pool of intestinal stem cells |
| topic | intestine intestinal stem cells Hippo YAP homeostasis regeneration |
| url | https://www.mdpi.com/2227-9059/8/12/560 |
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