Functional peptide KP24 enhances submandibular gland tissue growth in vitro
Introduction: Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiotherapy for head and neck cancer, autoimmune diseases, or aging. Xerostomia leads to oral health problems and thus affects the quality of life. Biological salivary gland tissue generated in vitro would pr...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-03-01
|
| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320416000195 |
| _version_ | 1828291458945253376 |
|---|---|
| author | Atsushi Ikeda Hiroaki Taketa Gulsan Ara Sathi Yoshiaki Hirano Seiji Iida Takuya Matsumoto |
| author_facet | Atsushi Ikeda Hiroaki Taketa Gulsan Ara Sathi Yoshiaki Hirano Seiji Iida Takuya Matsumoto |
| author_sort | Atsushi Ikeda |
| collection | DOAJ |
| description | Introduction: Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiotherapy for head and neck cancer, autoimmune diseases, or aging. Xerostomia leads to oral health problems and thus affects the quality of life. Biological salivary gland tissue generated in vitro would provide an alternative mode of treatment for this disease.
Methods: To develop a novel method for modulating salivary gland tissue growth in vitro, we prepared a KP24 peptide-immobilized hydrogel sheet, wherein the peptide comprised repeating proline and lysine sequences, and evaluated the effect of this peptide on salivary gland tissue growth.
Results: We found that the KP24 peptide has the potential to enhance glandular tissue growth in vitro. This enhancement is associated with neurite outgrowth and increasing neural innervation.
Conclusion: KP24 peptide modified material would be a promising material for the modulation of salivary gland tissue growth in vitro. |
| first_indexed | 2024-04-13T10:53:19Z |
| format | Article |
| id | doaj.art-5784d9353e1f4659ae22140fa169ee90 |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-04-13T10:53:19Z |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-5784d9353e1f4659ae22140fa169ee902022-12-22T02:49:36ZengElsevierRegenerative Therapy2352-32042016-03-013C10811310.1016/j.reth.2016.02.006Functional peptide KP24 enhances submandibular gland tissue growth in vitroAtsushi Ikeda0Hiroaki Taketa1Gulsan Ara Sathi2Yoshiaki Hirano3Seiji Iida4Takuya Matsumoto5Department of Biomaterials, Okayama University, 2-5-1 Shikata-Cho, Okayama, 700-8558, JapanDepartment of Biomaterials, Okayama University, 2-5-1 Shikata-Cho, Okayama, 700-8558, JapanDepartment of Biomaterials, Okayama University, 2-5-1 Shikata-Cho, Okayama, 700-8558, JapanDepartment of Chemical Engineering, Kansai University, 3-3-1 Yamate, Suita 564-8680, JapanDepartment of Oral and Maxillofacial Reconstructive Surgery, Okayama University, 2-5-1 Shikata-Cho, Okayama, 700-8558, JapanDepartment of Biomaterials, Okayama University, 2-5-1 Shikata-Cho, Okayama, 700-8558, JapanIntroduction: Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiotherapy for head and neck cancer, autoimmune diseases, or aging. Xerostomia leads to oral health problems and thus affects the quality of life. Biological salivary gland tissue generated in vitro would provide an alternative mode of treatment for this disease. Methods: To develop a novel method for modulating salivary gland tissue growth in vitro, we prepared a KP24 peptide-immobilized hydrogel sheet, wherein the peptide comprised repeating proline and lysine sequences, and evaluated the effect of this peptide on salivary gland tissue growth. Results: We found that the KP24 peptide has the potential to enhance glandular tissue growth in vitro. This enhancement is associated with neurite outgrowth and increasing neural innervation. Conclusion: KP24 peptide modified material would be a promising material for the modulation of salivary gland tissue growth in vitro.http://www.sciencedirect.com/science/article/pii/S2352320416000195Submandibular glandTissue manipulationFunctional peptideHydrogel |
| spellingShingle | Atsushi Ikeda Hiroaki Taketa Gulsan Ara Sathi Yoshiaki Hirano Seiji Iida Takuya Matsumoto Functional peptide KP24 enhances submandibular gland tissue growth in vitro Regenerative Therapy Submandibular gland Tissue manipulation Functional peptide Hydrogel |
| title | Functional peptide KP24 enhances submandibular gland tissue growth in vitro |
| title_full | Functional peptide KP24 enhances submandibular gland tissue growth in vitro |
| title_fullStr | Functional peptide KP24 enhances submandibular gland tissue growth in vitro |
| title_full_unstemmed | Functional peptide KP24 enhances submandibular gland tissue growth in vitro |
| title_short | Functional peptide KP24 enhances submandibular gland tissue growth in vitro |
| title_sort | functional peptide kp24 enhances submandibular gland tissue growth in vitro |
| topic | Submandibular gland Tissue manipulation Functional peptide Hydrogel |
| url | http://www.sciencedirect.com/science/article/pii/S2352320416000195 |
| work_keys_str_mv | AT atsushiikeda functionalpeptidekp24enhancessubmandibularglandtissuegrowthinvitro AT hiroakitaketa functionalpeptidekp24enhancessubmandibularglandtissuegrowthinvitro AT gulsanarasathi functionalpeptidekp24enhancessubmandibularglandtissuegrowthinvitro AT yoshiakihirano functionalpeptidekp24enhancessubmandibularglandtissuegrowthinvitro AT seijiiida functionalpeptidekp24enhancessubmandibularglandtissuegrowthinvitro AT takuyamatsumoto functionalpeptidekp24enhancessubmandibularglandtissuegrowthinvitro |