Late presentation of sorafenib-associated rash: a case report
<p>Abstract</p> <p>Introduction</p> <p>Sorafenib, an oral multitargeted tyrosine kinase inhibitor, is licensed for the treatment of hepatocellular carcinoma. Rash is one of the most common side effects of its use, generally appearing within days to a few weeks of commen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2010-10-01
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| Series: | Journal of Medical Case Reports |
| Online Access: | http://www.jmedicalcasereports.com/content/4/1/338 |
| _version_ | 1818228533226373120 |
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| author | Ross Paul Sarkodie Thomas |
| author_facet | Ross Paul Sarkodie Thomas |
| author_sort | Ross Paul |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>Sorafenib, an oral multitargeted tyrosine kinase inhibitor, is licensed for the treatment of hepatocellular carcinoma. Rash is one of the most common side effects of its use, generally appearing within days to a few weeks of commencing treatment. We report the first case of rash appearing nine months after starting treatment with sorafenib.</p> <p>Case presentation</p> <p>A 75-year-old Caucasian man initially presented with asymptomatic transient jaundice. He was diagnosed with Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma after extensive investigation. He tolerated sorafenib 400 mg twice a day before presenting nine months later with a rash, confirmed to be drug-induced.</p> <p>Conclusions</p> <p>Sorafenib is a drug of choice in Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma. It can cause protracted rash quite late into treatment. Successful management of the rash could contribute to achieving stable disease in hepatocellular carcinoma over a significant period of time.</p> |
| first_indexed | 2024-12-12T10:04:13Z |
| format | Article |
| id | doaj.art-578ffbd65f5143ad911fc5ce3ac34a5e |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-12T10:04:13Z |
| publishDate | 2010-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-578ffbd65f5143ad911fc5ce3ac34a5e2022-12-22T00:27:56ZengBMCJournal of Medical Case Reports1752-19472010-10-014133810.1186/1752-1947-4-338Late presentation of sorafenib-associated rash: a case reportRoss PaulSarkodie Thomas<p>Abstract</p> <p>Introduction</p> <p>Sorafenib, an oral multitargeted tyrosine kinase inhibitor, is licensed for the treatment of hepatocellular carcinoma. Rash is one of the most common side effects of its use, generally appearing within days to a few weeks of commencing treatment. We report the first case of rash appearing nine months after starting treatment with sorafenib.</p> <p>Case presentation</p> <p>A 75-year-old Caucasian man initially presented with asymptomatic transient jaundice. He was diagnosed with Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma after extensive investigation. He tolerated sorafenib 400 mg twice a day before presenting nine months later with a rash, confirmed to be drug-induced.</p> <p>Conclusions</p> <p>Sorafenib is a drug of choice in Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma. It can cause protracted rash quite late into treatment. Successful management of the rash could contribute to achieving stable disease in hepatocellular carcinoma over a significant period of time.</p>http://www.jmedicalcasereports.com/content/4/1/338 |
| spellingShingle | Ross Paul Sarkodie Thomas Late presentation of sorafenib-associated rash: a case report Journal of Medical Case Reports |
| title | Late presentation of sorafenib-associated rash: a case report |
| title_full | Late presentation of sorafenib-associated rash: a case report |
| title_fullStr | Late presentation of sorafenib-associated rash: a case report |
| title_full_unstemmed | Late presentation of sorafenib-associated rash: a case report |
| title_short | Late presentation of sorafenib-associated rash: a case report |
| title_sort | late presentation of sorafenib associated rash a case report |
| url | http://www.jmedicalcasereports.com/content/4/1/338 |
| work_keys_str_mv | AT rosspaul latepresentationofsorafenibassociatedrashacasereport AT sarkodiethomas latepresentationofsorafenibassociatedrashacasereport |