Update on the Management of Breast Cancer during Pregnancy
The diagnosis of breast cancer during pregnancy represents a challenging situation for the patient, her caregivers and physicians. Pregnancy adds complexity to oncological treatment planning, as many therapies can be potentially dangerous to the fetus. Therefore, a multidisciplinary approach is need...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/12/3616 |
| _version_ | 1797545813186969600 |
|---|---|
| author | Francesca Poggio Marco Tagliamento Chiara Pirrone Davide Soldato Benedetta Conte Chiara Molinelli Maurizio Cosso Piero Fregatti Lucia Del Mastro Matteo Lambertini |
| author_facet | Francesca Poggio Marco Tagliamento Chiara Pirrone Davide Soldato Benedetta Conte Chiara Molinelli Maurizio Cosso Piero Fregatti Lucia Del Mastro Matteo Lambertini |
| author_sort | Francesca Poggio |
| collection | DOAJ |
| description | The diagnosis of breast cancer during pregnancy represents a challenging situation for the patient, her caregivers and physicians. Pregnancy adds complexity to oncological treatment planning, as many therapies can be potentially dangerous to the fetus. Therefore, a multidisciplinary approach is needed to offer a proper care for obtaining the best possible outcomes for the mother and the future child. Breast surgery is feasible throughout the pregnancy while radiotherapy should be postponed after delivery. Administration of chemotherapy is considered safe and can be given during the second and third trimesters, while it is contraindicated in the first trimester due to the high risk of fetal malformations. Endocrine therapy and targeted agents are not recommended during the whole pregnancy period; however, limited data are available on the use of the majority of new anticancer drugs in this context. The aim of the current review is to provide an update on the current state of art about the management of women diagnosed with breast cancer during pregnancy. |
| first_indexed | 2024-03-10T14:21:18Z |
| format | Article |
| id | doaj.art-5794ae47d7d04be587fa21d562cc217e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T14:21:18Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5794ae47d7d04be587fa21d562cc217e2023-11-20T23:21:24ZengMDPI AGCancers2072-66942020-12-011212361610.3390/cancers12123616Update on the Management of Breast Cancer during PregnancyFrancesca Poggio0Marco Tagliamento1Chiara Pirrone2Davide Soldato3Benedetta Conte4Chiara Molinelli5Maurizio Cosso6Piero Fregatti7Lucia Del Mastro8Matteo Lambertini9Breast Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyU.O. Oncologia Medica 2, Medical Oncology Department, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyU.O. Oncologia Medica 2, Medical Oncology Department, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyU.O. Oncologia Medica 2, Medical Oncology Department, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyU.O. Oncologia Medica 2, Medical Oncology Department, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyU.O. Oncologia Medica 2, Medical Oncology Department, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyDepartment of Radiology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyU.O.C. Clinica di Chirurgia Senologica, Department of Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyBreast Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyDepartment of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, 16132 Genova, ItalyThe diagnosis of breast cancer during pregnancy represents a challenging situation for the patient, her caregivers and physicians. Pregnancy adds complexity to oncological treatment planning, as many therapies can be potentially dangerous to the fetus. Therefore, a multidisciplinary approach is needed to offer a proper care for obtaining the best possible outcomes for the mother and the future child. Breast surgery is feasible throughout the pregnancy while radiotherapy should be postponed after delivery. Administration of chemotherapy is considered safe and can be given during the second and third trimesters, while it is contraindicated in the first trimester due to the high risk of fetal malformations. Endocrine therapy and targeted agents are not recommended during the whole pregnancy period; however, limited data are available on the use of the majority of new anticancer drugs in this context. The aim of the current review is to provide an update on the current state of art about the management of women diagnosed with breast cancer during pregnancy.https://www.mdpi.com/2072-6694/12/12/3616pregnancy during breast cancerpregnancybreast cancersurgeryradiotherapychemotherapy |
| spellingShingle | Francesca Poggio Marco Tagliamento Chiara Pirrone Davide Soldato Benedetta Conte Chiara Molinelli Maurizio Cosso Piero Fregatti Lucia Del Mastro Matteo Lambertini Update on the Management of Breast Cancer during Pregnancy Cancers pregnancy during breast cancer pregnancy breast cancer surgery radiotherapy chemotherapy |
| title | Update on the Management of Breast Cancer during Pregnancy |
| title_full | Update on the Management of Breast Cancer during Pregnancy |
| title_fullStr | Update on the Management of Breast Cancer during Pregnancy |
| title_full_unstemmed | Update on the Management of Breast Cancer during Pregnancy |
| title_short | Update on the Management of Breast Cancer during Pregnancy |
| title_sort | update on the management of breast cancer during pregnancy |
| topic | pregnancy during breast cancer pregnancy breast cancer surgery radiotherapy chemotherapy |
| url | https://www.mdpi.com/2072-6694/12/12/3616 |
| work_keys_str_mv | AT francescapoggio updateonthemanagementofbreastcancerduringpregnancy AT marcotagliamento updateonthemanagementofbreastcancerduringpregnancy AT chiarapirrone updateonthemanagementofbreastcancerduringpregnancy AT davidesoldato updateonthemanagementofbreastcancerduringpregnancy AT benedettaconte updateonthemanagementofbreastcancerduringpregnancy AT chiaramolinelli updateonthemanagementofbreastcancerduringpregnancy AT mauriziocosso updateonthemanagementofbreastcancerduringpregnancy AT pierofregatti updateonthemanagementofbreastcancerduringpregnancy AT luciadelmastro updateonthemanagementofbreastcancerduringpregnancy AT matteolambertini updateonthemanagementofbreastcancerduringpregnancy |