Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles
Ubiquitin-like 3 (UBL3) is a well-conserved ubiquitin-like protein (UBL) in eukaryotes and regulates the ubiquitin cascade, but the significant roles of UBL3 in cellular processes remained unknown. Recently, UBL3 was elucidated to be a post-translational modification factor that promotes protein sor...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Japan Society for Cell Biology
2022-02-01
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| Series: | Cell Structure and Function |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/csf/47/1/47_21078/_html/-char/en |
| _version_ | 1797695345327603712 |
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| author | Yusuke Takanashi Tomoaki Kahyo Sae Kamamoto Hengsen Zhang Bin Chen Yashuang Ping Kiyomichi Mizuno Akikazu Kawase Kei Koizumi Masanori Satou Kazuhito Funai Norihiko Shiiya Mitsutoshi Setou |
| author_facet | Yusuke Takanashi Tomoaki Kahyo Sae Kamamoto Hengsen Zhang Bin Chen Yashuang Ping Kiyomichi Mizuno Akikazu Kawase Kei Koizumi Masanori Satou Kazuhito Funai Norihiko Shiiya Mitsutoshi Setou |
| author_sort | Yusuke Takanashi |
| collection | DOAJ |
| description | Ubiquitin-like 3 (UBL3) is a well-conserved ubiquitin-like protein (UBL) in eukaryotes and regulates the ubiquitin cascade, but the significant roles of UBL3 in cellular processes remained unknown. Recently, UBL3 was elucidated to be a post-translational modification factor that promotes protein sorting to small extracellular vesicles (sEVs). Proteins sorted into sEVs have been studied as etiologies of sEV-related diseases. Also, there have been attempts to construct drug delivery systems (DDSs) by loading proteins into sEVs. In this review, we introduce the new concept that UBL3 has a critical role in the protein-sorting system and compare structure conservation between UBL3 and other UBLs from an evolutionary perspective. We conclude with future perspectives for the utility of UBL3 in sEV-related diseases and DDS. Key words: UBL3, small extracellular vesicles, protein sorting, ubiquitin-like protein, post-translational modification |
| first_indexed | 2024-03-12T03:10:06Z |
| format | Article |
| id | doaj.art-579592aaa6494f4cbb7349c40f8f15e3 |
| institution | Directory Open Access Journal |
| issn | 0386-7196 1347-3700 |
| language | English |
| last_indexed | 2024-03-12T03:10:06Z |
| publishDate | 2022-02-01 |
| publisher | Japan Society for Cell Biology |
| record_format | Article |
| series | Cell Structure and Function |
| spelling | doaj.art-579592aaa6494f4cbb7349c40f8f15e32023-09-03T14:26:38ZengJapan Society for Cell BiologyCell Structure and Function0386-71961347-37002022-02-0147111810.1247/csf.21078csfUbiquitin-like 3 as a new protein-sorting factor for small extracellular vesiclesYusuke Takanashi0Tomoaki Kahyo1Sae Kamamoto2Hengsen Zhang3Bin Chen4Yashuang Ping5Kiyomichi Mizuno6Akikazu Kawase7Kei Koizumi8Masanori Satou9Kazuhito Funai10Norihiko Shiiya11Mitsutoshi Setou12Department of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineFirst Department of Surgery, Hamamatsu University School of MedicineFirst Department of Surgery, Hamamatsu University School of MedicineFirst Department of Surgery, Hamamatsu University School of MedicineFirst Department of Surgery, Hamamatsu University School of MedicineFirst Department of Surgery, Hamamatsu University School of MedicineFirst Department of Surgery, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineUbiquitin-like 3 (UBL3) is a well-conserved ubiquitin-like protein (UBL) in eukaryotes and regulates the ubiquitin cascade, but the significant roles of UBL3 in cellular processes remained unknown. Recently, UBL3 was elucidated to be a post-translational modification factor that promotes protein sorting to small extracellular vesicles (sEVs). Proteins sorted into sEVs have been studied as etiologies of sEV-related diseases. Also, there have been attempts to construct drug delivery systems (DDSs) by loading proteins into sEVs. In this review, we introduce the new concept that UBL3 has a critical role in the protein-sorting system and compare structure conservation between UBL3 and other UBLs from an evolutionary perspective. We conclude with future perspectives for the utility of UBL3 in sEV-related diseases and DDS. Key words: UBL3, small extracellular vesicles, protein sorting, ubiquitin-like protein, post-translational modificationhttps://www.jstage.jst.go.jp/article/csf/47/1/47_21078/_html/-char/enubl3small extracellular vesiclesprotein sortingubiquitin-like proteinpost-translational modification |
| spellingShingle | Yusuke Takanashi Tomoaki Kahyo Sae Kamamoto Hengsen Zhang Bin Chen Yashuang Ping Kiyomichi Mizuno Akikazu Kawase Kei Koizumi Masanori Satou Kazuhito Funai Norihiko Shiiya Mitsutoshi Setou Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles Cell Structure and Function ubl3 small extracellular vesicles protein sorting ubiquitin-like protein post-translational modification |
| title | Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles |
| title_full | Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles |
| title_fullStr | Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles |
| title_full_unstemmed | Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles |
| title_short | Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles |
| title_sort | ubiquitin like 3 as a new protein sorting factor for small extracellular vesicles |
| topic | ubl3 small extracellular vesicles protein sorting ubiquitin-like protein post-translational modification |
| url | https://www.jstage.jst.go.jp/article/csf/47/1/47_21078/_html/-char/en |
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