Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice
Abstract Background Epidemiological studies in China have revealed that Schistosoma japonicum infection is inversely correlated with metabolic syndrome, even after repeated chemotherapy with praziquantel (PZQ). We investigated the effect of chronic S. japonicum infection, PZQ chemotherapy, and solub...
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13071-017-2400-5 |
| _version_ | 1819087115223302144 |
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| author | Xiaofeng Luo Yuxiao Zhu Ran Liu Jingwei Song Fan Zhang Wenyue Zhang Zhipeng Xu Min Hou Bingya Yang Lin Chen Minjun Ji |
| author_facet | Xiaofeng Luo Yuxiao Zhu Ran Liu Jingwei Song Fan Zhang Wenyue Zhang Zhipeng Xu Min Hou Bingya Yang Lin Chen Minjun Ji |
| author_sort | Xiaofeng Luo |
| collection | DOAJ |
| description | Abstract Background Epidemiological studies in China have revealed that Schistosoma japonicum infection is inversely correlated with metabolic syndrome, even after repeated chemotherapy with praziquantel (PZQ). We investigated the effect of chronic S. japonicum infection, PZQ chemotherapy, and soluble egg antigen (SEA) treatment on whole-body metabolic homeostasis and hepatic insulin sensitivity in mouse models. Results Infection with S. japonicum was found to increase whole-body and hepatic insulin sensitivity in mice. PZQ chemotherapy significantly improved the physiological status of infected mice, maintaining Th2 immune-deviation and enhancing hepatic insulin sensitivity. Multiple linear regression analysis revealed positive correlations between anti-inflammatory cytokine expression and insulin signalling-related genes in the liver, as demonstrated by an in vitro stimulated hepatic cell line with IL-13 and IL-22. SEA treatment also improved the glucose tolerance and insulin sensitivity in Lepr db/db mice. Conclusions This study indicated that chronic S. japonicum infection with PZQ chemotherapy and SEA treatment can regulate metabolic homeostasis and protect against metabolic syndrome by promoting Th2 and regulatory responses in the liver. |
| first_indexed | 2024-12-21T21:31:01Z |
| format | Article |
| id | doaj.art-57962a49754f412b9ba0746642361832 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-21T21:31:01Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-57962a49754f412b9ba07466423618322022-12-21T18:49:38ZengBMCParasites & Vectors1756-33052017-10-0110111210.1186/s13071-017-2400-5Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in miceXiaofeng Luo0Yuxiao Zhu1Ran Liu2Jingwei Song3Fan Zhang4Wenyue Zhang5Zhipeng Xu6Min Hou7Bingya Yang8Lin Chen9Minjun Ji10Department of Pathogen Biology, Nanjing Medical UniversityDepartment of Pathogen Biology, Nanjing Medical UniversityDepartment of Pathogen Biology, Nanjing Medical UniversityDepartment of Pathogen Biology, Nanjing Medical UniversityDepartment of Pathogen Biology, Nanjing Medical UniversityDepartment of Pathogen Biology, Nanjing Medical UniversityDepartment of Pathogen Biology, Nanjing Medical UniversityDepartment of Pathogen Biology, Nanjing Medical UniversityDepartment of Pathogen Biology, Nanjing Medical UniversityDepartment of Pathogen Biology, Nanjing Medical UniversityDepartment of Pathogen Biology, Nanjing Medical UniversityAbstract Background Epidemiological studies in China have revealed that Schistosoma japonicum infection is inversely correlated with metabolic syndrome, even after repeated chemotherapy with praziquantel (PZQ). We investigated the effect of chronic S. japonicum infection, PZQ chemotherapy, and soluble egg antigen (SEA) treatment on whole-body metabolic homeostasis and hepatic insulin sensitivity in mouse models. Results Infection with S. japonicum was found to increase whole-body and hepatic insulin sensitivity in mice. PZQ chemotherapy significantly improved the physiological status of infected mice, maintaining Th2 immune-deviation and enhancing hepatic insulin sensitivity. Multiple linear regression analysis revealed positive correlations between anti-inflammatory cytokine expression and insulin signalling-related genes in the liver, as demonstrated by an in vitro stimulated hepatic cell line with IL-13 and IL-22. SEA treatment also improved the glucose tolerance and insulin sensitivity in Lepr db/db mice. Conclusions This study indicated that chronic S. japonicum infection with PZQ chemotherapy and SEA treatment can regulate metabolic homeostasis and protect against metabolic syndrome by promoting Th2 and regulatory responses in the liver.http://link.springer.com/article/10.1186/s13071-017-2400-5Schistosoma japonicumGlucose metabolismInsulin resistanceAnti-inflammatory cytokines |
| spellingShingle | Xiaofeng Luo Yuxiao Zhu Ran Liu Jingwei Song Fan Zhang Wenyue Zhang Zhipeng Xu Min Hou Bingya Yang Lin Chen Minjun Ji Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice Parasites & Vectors Schistosoma japonicum Glucose metabolism Insulin resistance Anti-inflammatory cytokines |
| title | Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice |
| title_full | Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice |
| title_fullStr | Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice |
| title_full_unstemmed | Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice |
| title_short | Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice |
| title_sort | praziquantel treatment after schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice |
| topic | Schistosoma japonicum Glucose metabolism Insulin resistance Anti-inflammatory cytokines |
| url | http://link.springer.com/article/10.1186/s13071-017-2400-5 |
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