VARFARIN DOSE REGIME APPROACHS BASED ON PHARMACOGENETICS TEST RESULTS: REAL POSSIBILITY TO OPTIMIZE THE PHARMACOTHERAPY
Indirect anticoagulants effectively prevent thromboembolic complications in patients with high risk of their development. It was proven in multicenter controlled studies. However in spite of efficient laboratory control of anticoagulant effect with the international normalized ratio, treatment with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-12-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/413 |
| _version_ | 1797232448843546624 |
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| author | D. A. Sychev I. M. Antonov S. V. Zagrebin N. A. Gasanov V. G. Kukes |
| author_facet | D. A. Sychev I. M. Antonov S. V. Zagrebin N. A. Gasanov V. G. Kukes |
| author_sort | D. A. Sychev |
| collection | DOAJ |
| description | Indirect anticoagulants effectively prevent thromboembolic complications in patients with high risk of their development. It was proven in multicenter controlled studies. However in spite of efficient laboratory control of anticoagulant effect with the international normalized ratio, treatment with drugs of this group deals with high risk of bleeding including fatal one. Latest decade studies showed that efficacy and safety of indirect anticoagulants significantly depend on genetic factors in the form of polymorphisms of genes of their biotransformation (CYP2C9) and molecule-targets (VKORC1). This created basis for usage of pharmacogenetics approach for individual choice of indirect anticoagulant dose regime. However to use this approach in clinical practice physician needs to have algorithms for choosing of indirect anticoagulant dose regime according to pharmocogenetics test results. Analysis of these existing algorithms, their advantages and disadvantages are described in the review. |
| first_indexed | 2024-03-08T14:05:52Z |
| format | Article |
| id | doaj.art-579657168c774709a1ec6876325da24a |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T16:00:27Z |
| publishDate | 2015-12-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-579657168c774709a1ec6876325da24a2024-04-01T07:43:25ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-12-0132596610.20996/1819-6446-2007-3-2-59-66413VARFARIN DOSE REGIME APPROACHS BASED ON PHARMACOGENETICS TEST RESULTS: REAL POSSIBILITY TO OPTIMIZE THE PHARMACOTHERAPYD. A. Sychev0I. M. Antonov1S. V. Zagrebin2N. A. Gasanov3V. G. Kukes4Moscow Medical Academy named after I.M. SechenovMoscow Medical Academy named after I.M. SechenovMoscow Medical Academy named after I.M. SechenovMoscow Medical Academy named after I.M. SechenovMoscow Medical Academy named after I.M. SechenovIndirect anticoagulants effectively prevent thromboembolic complications in patients with high risk of their development. It was proven in multicenter controlled studies. However in spite of efficient laboratory control of anticoagulant effect with the international normalized ratio, treatment with drugs of this group deals with high risk of bleeding including fatal one. Latest decade studies showed that efficacy and safety of indirect anticoagulants significantly depend on genetic factors in the form of polymorphisms of genes of their biotransformation (CYP2C9) and molecule-targets (VKORC1). This created basis for usage of pharmacogenetics approach for individual choice of indirect anticoagulant dose regime. However to use this approach in clinical practice physician needs to have algorithms for choosing of indirect anticoagulant dose regime according to pharmocogenetics test results. Analysis of these existing algorithms, their advantages and disadvantages are described in the review.https://www.rpcardio.online/jour/article/view/413pharmacogeneticsindirect anticoagulantsvarfarindose regimescyp2c9vkorc1 |
| spellingShingle | D. A. Sychev I. M. Antonov S. V. Zagrebin N. A. Gasanov V. G. Kukes VARFARIN DOSE REGIME APPROACHS BASED ON PHARMACOGENETICS TEST RESULTS: REAL POSSIBILITY TO OPTIMIZE THE PHARMACOTHERAPY Рациональная фармакотерапия в кардиологии pharmacogenetics indirect anticoagulants varfarin dose regimes cyp2c9 vkorc1 |
| title | VARFARIN DOSE REGIME APPROACHS BASED ON PHARMACOGENETICS TEST RESULTS: REAL POSSIBILITY TO OPTIMIZE THE PHARMACOTHERAPY |
| title_full | VARFARIN DOSE REGIME APPROACHS BASED ON PHARMACOGENETICS TEST RESULTS: REAL POSSIBILITY TO OPTIMIZE THE PHARMACOTHERAPY |
| title_fullStr | VARFARIN DOSE REGIME APPROACHS BASED ON PHARMACOGENETICS TEST RESULTS: REAL POSSIBILITY TO OPTIMIZE THE PHARMACOTHERAPY |
| title_full_unstemmed | VARFARIN DOSE REGIME APPROACHS BASED ON PHARMACOGENETICS TEST RESULTS: REAL POSSIBILITY TO OPTIMIZE THE PHARMACOTHERAPY |
| title_short | VARFARIN DOSE REGIME APPROACHS BASED ON PHARMACOGENETICS TEST RESULTS: REAL POSSIBILITY TO OPTIMIZE THE PHARMACOTHERAPY |
| title_sort | varfarin dose regime approachs based on pharmacogenetics test results real possibility to optimize the pharmacotherapy |
| topic | pharmacogenetics indirect anticoagulants varfarin dose regimes cyp2c9 vkorc1 |
| url | https://www.rpcardio.online/jour/article/view/413 |
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