The relationship between immune fitness and saliva biomarkers of systemic inflammation
Purpose: It is vital that Immune fitness, i.e., how well the immune system functions and reacts to challenges, can be reliably be examined. The current study aimed to compare immune fitness with assessments of saliva biomarkers of systemic inflammation. Methods: N = 108 healthy young adults (18–30-y...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354623000741 |
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| author | Kiki EW. Mulder Evi C. van Oostrom Marjolijn CE. Verheul Pauline A. Hendriksen Suzan Thijssen Mara AP. Diks Aletta D. Kraneveld Johan Garssen Joris C. Verster |
| author_facet | Kiki EW. Mulder Evi C. van Oostrom Marjolijn CE. Verheul Pauline A. Hendriksen Suzan Thijssen Mara AP. Diks Aletta D. Kraneveld Johan Garssen Joris C. Verster |
| author_sort | Kiki EW. Mulder |
| collection | DOAJ |
| description | Purpose: It is vital that Immune fitness, i.e., how well the immune system functions and reacts to challenges, can be reliably be examined. The current study aimed to compare immune fitness with assessments of saliva biomarkers of systemic inflammation. Methods: N = 108 healthy young adults (18–30-year-old students of Utrecht University, the Netherlands) participated in the study. A saliva sample was collected for biomarker assessment (Interleukin (IL)-1β, IL-6, IL-8, IL-10, immunoglobulin A (IgA), and tumor necrosis factor-alpha (TNF-α), and c-reactive protein (CRP). Additionally, a survey was completed to assess immune fitness, mood, mental resilience, and quality of life. The correlations between the biomarker assessments, immune fitness and mood were determined. Results: No significant correlations between immune fitness and biomarkers of systemic inflammation were found. Significant sex differences in correlations with immune fitness were demonstrated for loneliness (significant only in men) and fatigue (significant only in women). For both sexes, immune fitness correlated significantly with anxiety, mental resilience, and quality of life. Conclusion: No significant correlations were found between immune fitness and saliva biomarkers of systemic inflammation. Immune fitness correlated significantly with anxiety, mental resilience, and quality of life. Sex differences were demonstrated in the relation of immune fitness with loneliness and fatigue. Future research should further investigate factors that may influence the relationship between immune fitness, mood, and biomarkers of systemic inflammation, including underlying psychological mechanisms of possible sex differences. |
| first_indexed | 2024-03-13T00:46:22Z |
| format | Article |
| id | doaj.art-579693e4809740cebe170988283947f4 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-03-13T00:46:22Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-579693e4809740cebe170988283947f42023-07-09T04:22:26ZengElsevierBrain, Behavior, & Immunity - Health2666-35462023-08-0131100660The relationship between immune fitness and saliva biomarkers of systemic inflammationKiki EW. Mulder0Evi C. van Oostrom1Marjolijn CE. Verheul2Pauline A. Hendriksen3Suzan Thijssen4Mara AP. Diks5Aletta D. Kraneveld6Johan Garssen7Joris C. Verster8Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG, Utrecht, the NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG, Utrecht, the NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG, Utrecht, the NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG, Utrecht, the NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG, Utrecht, the NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG, Utrecht, the NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG, Utrecht, the NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG, Utrecht, the Netherlands; Global Centre of Excellence Immunology, Nutricia Danone Research, 3584CT, Utrecht, the NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG, Utrecht, the Netherlands; Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC, 3122, Australia; Corresponding author. Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584CG Utrecht, the Netherlands.Purpose: It is vital that Immune fitness, i.e., how well the immune system functions and reacts to challenges, can be reliably be examined. The current study aimed to compare immune fitness with assessments of saliva biomarkers of systemic inflammation. Methods: N = 108 healthy young adults (18–30-year-old students of Utrecht University, the Netherlands) participated in the study. A saliva sample was collected for biomarker assessment (Interleukin (IL)-1β, IL-6, IL-8, IL-10, immunoglobulin A (IgA), and tumor necrosis factor-alpha (TNF-α), and c-reactive protein (CRP). Additionally, a survey was completed to assess immune fitness, mood, mental resilience, and quality of life. The correlations between the biomarker assessments, immune fitness and mood were determined. Results: No significant correlations between immune fitness and biomarkers of systemic inflammation were found. Significant sex differences in correlations with immune fitness were demonstrated for loneliness (significant only in men) and fatigue (significant only in women). For both sexes, immune fitness correlated significantly with anxiety, mental resilience, and quality of life. Conclusion: No significant correlations were found between immune fitness and saliva biomarkers of systemic inflammation. Immune fitness correlated significantly with anxiety, mental resilience, and quality of life. Sex differences were demonstrated in the relation of immune fitness with loneliness and fatigue. Future research should further investigate factors that may influence the relationship between immune fitness, mood, and biomarkers of systemic inflammation, including underlying psychological mechanisms of possible sex differences.http://www.sciencedirect.com/science/article/pii/S2666354623000741Immune fitnessAssessmentCytokinesc-reactive proteinImmunoglobulin ASex differences |
| spellingShingle | Kiki EW. Mulder Evi C. van Oostrom Marjolijn CE. Verheul Pauline A. Hendriksen Suzan Thijssen Mara AP. Diks Aletta D. Kraneveld Johan Garssen Joris C. Verster The relationship between immune fitness and saliva biomarkers of systemic inflammation Brain, Behavior, & Immunity - Health Immune fitness Assessment Cytokines c-reactive protein Immunoglobulin A Sex differences |
| title | The relationship between immune fitness and saliva biomarkers of systemic inflammation |
| title_full | The relationship between immune fitness and saliva biomarkers of systemic inflammation |
| title_fullStr | The relationship between immune fitness and saliva biomarkers of systemic inflammation |
| title_full_unstemmed | The relationship between immune fitness and saliva biomarkers of systemic inflammation |
| title_short | The relationship between immune fitness and saliva biomarkers of systemic inflammation |
| title_sort | relationship between immune fitness and saliva biomarkers of systemic inflammation |
| topic | Immune fitness Assessment Cytokines c-reactive protein Immunoglobulin A Sex differences |
| url | http://www.sciencedirect.com/science/article/pii/S2666354623000741 |
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