Peripheral Endocannabinoid Components and Lipid Plasma Levels in Patients with Resistant Migraine and Co-Morbid Personality and Psychological Disorders: A Cross-Sectional Study
Resistant migraine characterizes those patients who have failed at least three classes of migraine prophylaxis. These difficult-to-treat patients are likely to be characterized by a high prevalence of psychological disturbances. A dysfunction of the endocannabinoid system (ECS), including alteration...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/3/1893 |
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| author | Sara Bottiroli Rosaria Greco Valentina Franco Annamaria Zanaboni Michela Palmisani Gloria Vaghi Grazia Sances Roberto De Icco Cristina Tassorelli |
| author_facet | Sara Bottiroli Rosaria Greco Valentina Franco Annamaria Zanaboni Michela Palmisani Gloria Vaghi Grazia Sances Roberto De Icco Cristina Tassorelli |
| author_sort | Sara Bottiroli |
| collection | DOAJ |
| description | Resistant migraine characterizes those patients who have failed at least three classes of migraine prophylaxis. These difficult-to-treat patients are likely to be characterized by a high prevalence of psychological disturbances. A dysfunction of the endocannabinoid system (ECS), including alteration in the levels of endocannabinoid congeners, may underlie several psychiatric disorders and the pathogenesis of migraines. Here we explored whether the peripheral gene expression of major components of the ECS and the plasma levels of endocannabinoids and related lipids are associated with psychological disorders in resistant migraine. Fifty-one patients (age = 46.0 ± 11.7) with resistant migraine received a comprehensive psychological evaluation according to the DSM-5 criteria. Among the patients, 61% had personality disorders (PD) and 61% had mood disorders (MD). Several associations were found between these psychological disorders and peripheral ECS alterations. Lower plasma levels of palmitoiletanolamide (PEA) were found in the PD group compared with the non-PD group. The MD group was characterized by lower mRNA levels of diacylglycerol lipase α (<i>DAGL</i>α) and <i>CB2</i> (cannabinoid-2) receptor. The results suggest the existence of peripheral dysfunction in some components of the ECS and an alteration in plasma levels of PEA in patients with resistant migraine and mood or personality disorders. |
| first_indexed | 2024-03-08T03:54:36Z |
| format | Article |
| id | doaj.art-579a3bef0279461e951786fdd9391bba |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T03:54:36Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-579a3bef0279461e951786fdd9391bba2024-02-09T15:15:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01253189310.3390/ijms25031893Peripheral Endocannabinoid Components and Lipid Plasma Levels in Patients with Resistant Migraine and Co-Morbid Personality and Psychological Disorders: A Cross-Sectional StudySara Bottiroli0Rosaria Greco1Valentina Franco2Annamaria Zanaboni3Michela Palmisani4Gloria Vaghi5Grazia Sances6Roberto De Icco7Cristina Tassorelli8Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, ItalyHeadache Science and Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, ItalyHeadache Science and Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, ItalyHeadache Science and Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, ItalyHeadache Science and Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, ItalyResistant migraine characterizes those patients who have failed at least three classes of migraine prophylaxis. These difficult-to-treat patients are likely to be characterized by a high prevalence of psychological disturbances. A dysfunction of the endocannabinoid system (ECS), including alteration in the levels of endocannabinoid congeners, may underlie several psychiatric disorders and the pathogenesis of migraines. Here we explored whether the peripheral gene expression of major components of the ECS and the plasma levels of endocannabinoids and related lipids are associated with psychological disorders in resistant migraine. Fifty-one patients (age = 46.0 ± 11.7) with resistant migraine received a comprehensive psychological evaluation according to the DSM-5 criteria. Among the patients, 61% had personality disorders (PD) and 61% had mood disorders (MD). Several associations were found between these psychological disorders and peripheral ECS alterations. Lower plasma levels of palmitoiletanolamide (PEA) were found in the PD group compared with the non-PD group. The MD group was characterized by lower mRNA levels of diacylglycerol lipase α (<i>DAGL</i>α) and <i>CB2</i> (cannabinoid-2) receptor. The results suggest the existence of peripheral dysfunction in some components of the ECS and an alteration in plasma levels of PEA in patients with resistant migraine and mood or personality disorders.https://www.mdpi.com/1422-0067/25/3/1893resistant migraineendocannabinoid systempersonality disorderspsychological comorbiditiesdepression |
| spellingShingle | Sara Bottiroli Rosaria Greco Valentina Franco Annamaria Zanaboni Michela Palmisani Gloria Vaghi Grazia Sances Roberto De Icco Cristina Tassorelli Peripheral Endocannabinoid Components and Lipid Plasma Levels in Patients with Resistant Migraine and Co-Morbid Personality and Psychological Disorders: A Cross-Sectional Study International Journal of Molecular Sciences resistant migraine endocannabinoid system personality disorders psychological comorbidities depression |
| title | Peripheral Endocannabinoid Components and Lipid Plasma Levels in Patients with Resistant Migraine and Co-Morbid Personality and Psychological Disorders: A Cross-Sectional Study |
| title_full | Peripheral Endocannabinoid Components and Lipid Plasma Levels in Patients with Resistant Migraine and Co-Morbid Personality and Psychological Disorders: A Cross-Sectional Study |
| title_fullStr | Peripheral Endocannabinoid Components and Lipid Plasma Levels in Patients with Resistant Migraine and Co-Morbid Personality and Psychological Disorders: A Cross-Sectional Study |
| title_full_unstemmed | Peripheral Endocannabinoid Components and Lipid Plasma Levels in Patients with Resistant Migraine and Co-Morbid Personality and Psychological Disorders: A Cross-Sectional Study |
| title_short | Peripheral Endocannabinoid Components and Lipid Plasma Levels in Patients with Resistant Migraine and Co-Morbid Personality and Psychological Disorders: A Cross-Sectional Study |
| title_sort | peripheral endocannabinoid components and lipid plasma levels in patients with resistant migraine and co morbid personality and psychological disorders a cross sectional study |
| topic | resistant migraine endocannabinoid system personality disorders psychological comorbidities depression |
| url | https://www.mdpi.com/1422-0067/25/3/1893 |
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