Probing the functional impact of sub-retinal prosthesis
Retinal prostheses are promising tools for recovering visual functions in blind patients but, unfortunately, with still poor gains in visual acuity. Improving their resolution is thus a key challenge that warrants understanding its origin through appropriate animal models. Here, we provide a systema...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/12687 |
| _version_ | 1818018987064164352 |
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| author | Sébastien Roux Frédéric Matonti Florent Dupont Louis Hoffart Sylvain Takerkart Serge Picaud Pascale Pham Frédéric Chavane |
| author_facet | Sébastien Roux Frédéric Matonti Florent Dupont Louis Hoffart Sylvain Takerkart Serge Picaud Pascale Pham Frédéric Chavane |
| author_sort | Sébastien Roux |
| collection | DOAJ |
| description | Retinal prostheses are promising tools for recovering visual functions in blind patients but, unfortunately, with still poor gains in visual acuity. Improving their resolution is thus a key challenge that warrants understanding its origin through appropriate animal models. Here, we provide a systematic comparison between visual and prosthetic activations of the rat primary visual cortex (V1). We established a precise V1 mapping as a functional benchmark to demonstrate that sub-retinal implants activate V1 at the appropriate position, scalable to a wide range of visual luminance, but with an aspect-ratio and an extent much larger than expected. Such distorted activation profile can be accounted for by the existence of two sources of diffusion, passive diffusion and activation of ganglion cells’ axons en passant. Reverse-engineered electrical pulses based on impedance spectroscopy is the only solution we tested that decreases the extent and aspect-ratio, providing a promising solution for clinical applications. |
| first_indexed | 2024-04-14T07:47:04Z |
| format | Article |
| id | doaj.art-579b17163009418a95cb7dd8597b36ab |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:47:04Z |
| publishDate | 2016-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-579b17163009418a95cb7dd8597b36ab2022-12-22T02:05:18ZengeLife Sciences Publications LtdeLife2050-084X2016-08-01510.7554/eLife.12687Probing the functional impact of sub-retinal prosthesisSébastien Roux0https://orcid.org/0000-0003-2366-6430Frédéric Matonti1Florent Dupont2Louis Hoffart3Sylvain Takerkart4Serge Picaud5Pascale Pham6Frédéric Chavane7Institut de Neurosciences de la Timone, CNRS, Aix-Marseille Université, Marseille, FranceInstitut de Neurosciences de la Timone, CNRS, Aix-Marseille Université, Marseille, France; Ophthalmology Department, Aix Marseille Université, Hôpital Nord,Hôpital de la Timone, Marseille, FranceCEA-LETI, Grenoble, France; Université Grenoble Alpes, Grenoble, FranceInstitut de Neurosciences de la Timone, CNRS, Aix-Marseille Université, Marseille, France; Ophthalmology Department, Aix Marseille Université, Hôpital Nord,Hôpital de la Timone, Marseille, FranceInstitut de Neurosciences de la Timone, CNRS, Aix-Marseille Université, Marseille, FranceInserm, UMRS-986, Institut de la vision, Paris, FranceCEA-LETI, Grenoble, France; Université Grenoble Alpes, Grenoble, FranceInstitut de Neurosciences de la Timone, CNRS, Aix-Marseille Université, Marseille, FranceRetinal prostheses are promising tools for recovering visual functions in blind patients but, unfortunately, with still poor gains in visual acuity. Improving their resolution is thus a key challenge that warrants understanding its origin through appropriate animal models. Here, we provide a systematic comparison between visual and prosthetic activations of the rat primary visual cortex (V1). We established a precise V1 mapping as a functional benchmark to demonstrate that sub-retinal implants activate V1 at the appropriate position, scalable to a wide range of visual luminance, but with an aspect-ratio and an extent much larger than expected. Such distorted activation profile can be accounted for by the existence of two sources of diffusion, passive diffusion and activation of ganglion cells’ axons en passant. Reverse-engineered electrical pulses based on impedance spectroscopy is the only solution we tested that decreases the extent and aspect-ratio, providing a promising solution for clinical applications.https://elifesciences.org/articles/12687primary visual cortexretinal implantsoptical imagingimpedance spectroscopyartificial visual acuity |
| spellingShingle | Sébastien Roux Frédéric Matonti Florent Dupont Louis Hoffart Sylvain Takerkart Serge Picaud Pascale Pham Frédéric Chavane Probing the functional impact of sub-retinal prosthesis eLife primary visual cortex retinal implants optical imaging impedance spectroscopy artificial visual acuity |
| title | Probing the functional impact of sub-retinal prosthesis |
| title_full | Probing the functional impact of sub-retinal prosthesis |
| title_fullStr | Probing the functional impact of sub-retinal prosthesis |
| title_full_unstemmed | Probing the functional impact of sub-retinal prosthesis |
| title_short | Probing the functional impact of sub-retinal prosthesis |
| title_sort | probing the functional impact of sub retinal prosthesis |
| topic | primary visual cortex retinal implants optical imaging impedance spectroscopy artificial visual acuity |
| url | https://elifesciences.org/articles/12687 |
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