The correlation of endothelin-1 and dyslipidemia in migraineurs
<strong>Objective</strong> To detect the levels of serum lipid and endothelin-1 (ET-1) in acute period migraine, and to observe the correlation between them. <strong>Methods</strong> The serum lipid level in healthy control group (N = 42) and migraine group (N = 95) was detec...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Tianjin Huanhu Hospital
2013-09-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/803 |
| _version_ | 1818257846011166720 |
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| author | Zhong-ju ZHANG Li YANG |
| author_facet | Zhong-ju ZHANG Li YANG |
| author_sort | Zhong-ju ZHANG |
| collection | DOAJ |
| description | <strong>Objective</strong> To detect the levels of serum lipid and endothelin-1 (ET-1) in acute period migraine, and to observe the correlation between them. <strong>Methods</strong> The serum lipid level in healthy control group (N = 42) and migraine group (N = 95) was detected by automatic biochemical detector and serum ET-1 level of two groups was measured by radioimmunoassay method. <strong>Results</strong> Compared with healthy control group, the levels of total cholesterol (TC), trighyceride (TG), low-density lipoprotein cholesterol (LDL-C) and ET-1 in migraine group, especially patients with dyslipidemia, were significantly higher (P < 0.05, for all), while the difference of high-density lipoprotein cholesterol (HDL-C) level had no statistical significance (P > 0.05). Serum ET-1 content in migraine group was positively correlated with the levels of TC (rs = 0.208, P = 0.043), TG (rs = 0.331, P = 0.001), LDL-C (rs = 0.217, P = 0.035), but was not correlated with HDL-C level (rs = -0.099, P = 0.341). <strong>Conclusion</strong> The changes of serum lipid and ET-1 level play an important role in the process of migraine attacks. Serum ET-1 has positive correlation with TG, TC, LDL-C levels, suggesting the correlation of serum lipid and ET-1 in acute period migraineurs and effective control for serum lipid has important significance for the prevention of migraine and cardiovascular diseases. |
| first_indexed | 2024-12-12T17:50:08Z |
| format | Article |
| id | doaj.art-579e2367147b44848e40415e660cf061 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-12T17:50:08Z |
| publishDate | 2013-09-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-579e2367147b44848e40415e660cf0612022-12-22T00:16:50ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312013-09-01139783786802The correlation of endothelin-1 and dyslipidemia in migraineursZhong-ju ZHANGLi YANG<strong>Objective</strong> To detect the levels of serum lipid and endothelin-1 (ET-1) in acute period migraine, and to observe the correlation between them. <strong>Methods</strong> The serum lipid level in healthy control group (N = 42) and migraine group (N = 95) was detected by automatic biochemical detector and serum ET-1 level of two groups was measured by radioimmunoassay method. <strong>Results</strong> Compared with healthy control group, the levels of total cholesterol (TC), trighyceride (TG), low-density lipoprotein cholesterol (LDL-C) and ET-1 in migraine group, especially patients with dyslipidemia, were significantly higher (P < 0.05, for all), while the difference of high-density lipoprotein cholesterol (HDL-C) level had no statistical significance (P > 0.05). Serum ET-1 content in migraine group was positively correlated with the levels of TC (rs = 0.208, P = 0.043), TG (rs = 0.331, P = 0.001), LDL-C (rs = 0.217, P = 0.035), but was not correlated with HDL-C level (rs = -0.099, P = 0.341). <strong>Conclusion</strong> The changes of serum lipid and ET-1 level play an important role in the process of migraine attacks. Serum ET-1 has positive correlation with TG, TC, LDL-C levels, suggesting the correlation of serum lipid and ET-1 in acute period migraineurs and effective control for serum lipid has important significance for the prevention of migraine and cardiovascular diseases.http://www.cjcnn.org/index.php/cjcnn/article/view/803Migraine disordersEndothelinsHyperlipidemias |
| spellingShingle | Zhong-ju ZHANG Li YANG The correlation of endothelin-1 and dyslipidemia in migraineurs Chinese Journal of Contemporary Neurology and Neurosurgery Migraine disorders Endothelins Hyperlipidemias |
| title | The correlation of endothelin-1 and dyslipidemia in migraineurs |
| title_full | The correlation of endothelin-1 and dyslipidemia in migraineurs |
| title_fullStr | The correlation of endothelin-1 and dyslipidemia in migraineurs |
| title_full_unstemmed | The correlation of endothelin-1 and dyslipidemia in migraineurs |
| title_short | The correlation of endothelin-1 and dyslipidemia in migraineurs |
| title_sort | correlation of endothelin 1 and dyslipidemia in migraineurs |
| topic | Migraine disorders Endothelins Hyperlipidemias |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/803 |
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