Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function
(1) Background: With unknown causes and no effective treatment available, Alzheimer’s disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/7/1350 |
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| author | Xuexia Li Qingqing Shi Hao Xu Yufang Xiong Chao Wang Linfeng Le Junliang Lian Guoli Wu Feiyuan Peng Qiong Liu Xiubo Du |
| author_facet | Xuexia Li Qingqing Shi Hao Xu Yufang Xiong Chao Wang Linfeng Le Junliang Lian Guoli Wu Feiyuan Peng Qiong Liu Xiubo Du |
| author_sort | Xuexia Li |
| collection | DOAJ |
| description | (1) Background: With unknown causes and no effective treatment available, Alzheimer’s disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviated the related pathological indicators but showed toxicity to the mice. Here, we dedicated to study the therapeutic effect and molecular mechanism of Ebselen at a much lower concentration on 3×Tg-AD mice. (2) Methods: Various behavioral experiments were applied to detect the behavioral ability of mice. Western blot, thioflavin T staining and a transmission electron microscope were used to evaluate the pathology of AD mice. The mitochondrial membrane potential and respiration were assessed with the corresponding assay kit. (3) Results: Ebselen remarkably increased cognitive ability of AD mice, eliminated β-Amyloid (Aβ) oligomers and recovered the synaptic damage in AD mice brain. In addition, the destroyed mitochondrial morphologies and function were repaired by Ebselen through ameliorating mitochondrial energy metabolism, mitochondrial biogenesis and mitochondrial fusion/fission balance in N2a-SW cells and brain tissues of AD mice. (4) Conclusions: This research indicated that Ebselen might exert its therapeutic effect via protecting mitochondria in AD. |
| first_indexed | 2024-03-09T12:19:46Z |
| format | Article |
| id | doaj.art-579f88facafc48018ea4a64028007cb0 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T12:19:46Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-579f88facafc48018ea4a64028007cb02023-11-30T22:42:36ZengMDPI AGAntioxidants2076-39212022-07-01117135010.3390/antiox11071350Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial FunctionXuexia Li0Qingqing Shi1Hao Xu2Yufang Xiong3Chao Wang4Linfeng Le5Junliang Lian6Guoli Wu7Feiyuan Peng8Qiong Liu9Xiubo Du10Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaDepartment of Psychiatry, Xijing Hospital, Air Force Medical University, Xi’an 710032, ChinaGuangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaGuangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaShenzhen Center for Disease Control and Prevention, Shenzhen 518055, ChinaGuangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaGuangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaGuangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaGuangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaGuangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, ChinaGuangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, China(1) Background: With unknown causes and no effective treatment available, Alzheimer’s disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviated the related pathological indicators but showed toxicity to the mice. Here, we dedicated to study the therapeutic effect and molecular mechanism of Ebselen at a much lower concentration on 3×Tg-AD mice. (2) Methods: Various behavioral experiments were applied to detect the behavioral ability of mice. Western blot, thioflavin T staining and a transmission electron microscope were used to evaluate the pathology of AD mice. The mitochondrial membrane potential and respiration were assessed with the corresponding assay kit. (3) Results: Ebselen remarkably increased cognitive ability of AD mice, eliminated β-Amyloid (Aβ) oligomers and recovered the synaptic damage in AD mice brain. In addition, the destroyed mitochondrial morphologies and function were repaired by Ebselen through ameliorating mitochondrial energy metabolism, mitochondrial biogenesis and mitochondrial fusion/fission balance in N2a-SW cells and brain tissues of AD mice. (4) Conclusions: This research indicated that Ebselen might exert its therapeutic effect via protecting mitochondria in AD.https://www.mdpi.com/2076-3921/11/7/1350Alzheimer’s diseaseEbselensynapseAβmitochondria |
| spellingShingle | Xuexia Li Qingqing Shi Hao Xu Yufang Xiong Chao Wang Linfeng Le Junliang Lian Guoli Wu Feiyuan Peng Qiong Liu Xiubo Du Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function Antioxidants Alzheimer’s disease Ebselen synapse Aβ mitochondria |
| title | Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
| title_full | Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
| title_fullStr | Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
| title_full_unstemmed | Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
| title_short | Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function |
| title_sort | ebselen interferes with alzheimer s disease by regulating mitochondrial function |
| topic | Alzheimer’s disease Ebselen synapse Aβ mitochondria |
| url | https://www.mdpi.com/2076-3921/11/7/1350 |
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