Stature–weight growth delays: Clinical and etiological aspects
Background: Stature–weight growth delay (SWGD) is a frequent motivation of consultation. It could be a consequence of a known chronic affection, congenital or acquired affection. The purpose of this study is to describe epidemiological, clinical, paraclinical, and etiological aspects of SWGD. Patien...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2018;volume=7;issue=5;spage=963;epage=966;aulast=Salhi |
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| author | Houda Salhi Asmae Lahlou Mamadou L Dante Hanan El Ouahabi Saïd Boujraf Farida Ajdi |
| author_facet | Houda Salhi Asmae Lahlou Mamadou L Dante Hanan El Ouahabi Saïd Boujraf Farida Ajdi |
| author_sort | Houda Salhi |
| collection | DOAJ |
| description | Background: Stature–weight growth delay (SWGD) is a frequent motivation of consultation. It could be a consequence of a known chronic affection, congenital or acquired affection. The purpose of this study is to describe epidemiological, clinical, paraclinical, and etiological aspects of SWGD. Patients and Methods: This retrospective study included 103 patients presenting a growth delay with an average age of 14.44 years and ranging between 5 and 21 years. Male predominance was noticed in 68.93% of cases. Patients showed a stature lower to −2 standard deviation (SD) for corresponding age compared to Sempe and Pedron reference. Patients were hospitalized in Endocrinology and Metabolic Diseases Department of the University Hospital of Fez, Fez, Morocco. Results: Patient's history included a perinatal suffering in 6.7% of cases, a chronic pathology follow-up in 17.6% of cases, and psychomotor development disorder in 10.6% of cases. The average weight was −2.37 SD with extremes varying from −4 to −0.5 SD. The stature values varied between −4.5 and −2 SD for the given age, with an average of −3.12 SD. A severe stature delay (< −3 SD) was recorded in 39.6% of cases and the targeted average size was −2.44 SD with extremes varying from −4 to −1.5 SD. Growth delay etiologies were dominated by a deficit in growth hormones (GHs) in 60% of cases. Discussion and Conclusion: Dynamic tests objectified a total deficit and partial deficits in GH in 41.7 and 30% of patients, respectively. The hypothalamo–pituitary magnetic resonance imaging was pathological in 23.3% of patients and showed a syndrome of interruption of pituitary stem in seven patients, pituitary hail gland in three patients, a craniopharyngioma in two patients, prolactin microadenoma in one patient, and nonfunctional pituitary microadenoma in one patient. GH treatment was established in 16 children that were presenting a deficit in GH, and two girls presenting Turner syndrome, whereas etiological treatment was suggested in all remaining cases. |
| first_indexed | 2024-12-12T07:35:01Z |
| format | Article |
| id | doaj.art-57a0cc81b13c4c56b1a75ea94b69374a |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-12T07:35:01Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-57a0cc81b13c4c56b1a75ea94b69374a2022-12-22T00:32:56ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632018-01-017596396610.4103/jfmpc.jfmpc_207_16Stature–weight growth delays: Clinical and etiological aspectsHouda SalhiAsmae LahlouMamadou L DanteHanan El OuahabiSaïd BoujrafFarida AjdiBackground: Stature–weight growth delay (SWGD) is a frequent motivation of consultation. It could be a consequence of a known chronic affection, congenital or acquired affection. The purpose of this study is to describe epidemiological, clinical, paraclinical, and etiological aspects of SWGD. Patients and Methods: This retrospective study included 103 patients presenting a growth delay with an average age of 14.44 years and ranging between 5 and 21 years. Male predominance was noticed in 68.93% of cases. Patients showed a stature lower to −2 standard deviation (SD) for corresponding age compared to Sempe and Pedron reference. Patients were hospitalized in Endocrinology and Metabolic Diseases Department of the University Hospital of Fez, Fez, Morocco. Results: Patient's history included a perinatal suffering in 6.7% of cases, a chronic pathology follow-up in 17.6% of cases, and psychomotor development disorder in 10.6% of cases. The average weight was −2.37 SD with extremes varying from −4 to −0.5 SD. The stature values varied between −4.5 and −2 SD for the given age, with an average of −3.12 SD. A severe stature delay (< −3 SD) was recorded in 39.6% of cases and the targeted average size was −2.44 SD with extremes varying from −4 to −1.5 SD. Growth delay etiologies were dominated by a deficit in growth hormones (GHs) in 60% of cases. Discussion and Conclusion: Dynamic tests objectified a total deficit and partial deficits in GH in 41.7 and 30% of patients, respectively. The hypothalamo–pituitary magnetic resonance imaging was pathological in 23.3% of patients and showed a syndrome of interruption of pituitary stem in seven patients, pituitary hail gland in three patients, a craniopharyngioma in two patients, prolactin microadenoma in one patient, and nonfunctional pituitary microadenoma in one patient. GH treatment was established in 16 children that were presenting a deficit in GH, and two girls presenting Turner syndrome, whereas etiological treatment was suggested in all remaining cases.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2018;volume=7;issue=5;spage=963;epage=966;aulast=SalhiClinicaldelaysetiologicalgrowthstatureweight |
| spellingShingle | Houda Salhi Asmae Lahlou Mamadou L Dante Hanan El Ouahabi Saïd Boujraf Farida Ajdi Stature–weight growth delays: Clinical and etiological aspects Journal of Family Medicine and Primary Care Clinical delays etiological growth stature weight |
| title | Stature–weight growth delays: Clinical and etiological aspects |
| title_full | Stature–weight growth delays: Clinical and etiological aspects |
| title_fullStr | Stature–weight growth delays: Clinical and etiological aspects |
| title_full_unstemmed | Stature–weight growth delays: Clinical and etiological aspects |
| title_short | Stature–weight growth delays: Clinical and etiological aspects |
| title_sort | stature weight growth delays clinical and etiological aspects |
| topic | Clinical delays etiological growth stature weight |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2018;volume=7;issue=5;spage=963;epage=966;aulast=Salhi |
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