Tissue-Specific Regulation of HNK-1 Biosynthesis by Bisecting GlcNAc

Tissue-Specific Regulation of HNK-1 Biosynthesis by Bisecting GlcNAc

Human natural killer—1 (HNK-1) is a sulfated glyco-epitope regulating cell adhesion and synaptic functions. HNK-1 and its non-sulfated forms, which are specifically expressed in the brain and the kidney, respectively, are distinctly biosynthesized by two homologous glycosyltransferases: GlcAT-P in t...

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Bibliographic Details
Main Authors: Haruka Kawade, Jyoji Morise, Sushil K. Mishra, Shuta Tsujioka, Shogo Oka, Yasuhiko Kizuka
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
bisecting GlcNAc
glucuronyltransferase P (GlcAT-P)
glucuronyltransferase S (GlcAT-S)
glycosylation
<i>N</i>-acetylglucosaminyltransferase III (GnT-III)
human natural killer—1 (HNK-1)
Online Access:https://www.mdpi.com/1420-3049/26/17/5176

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