Matrix metalloproteinase-8 (MMP-8) and its inhibitors: A minireview
The type-II collagenase, also known as matrix metalloproteinase-8 (MMP-8) plays a vital role in a variety of physiological illnesses namely cardiovascular, musculoskeletal, renal, digestive, and respiratory ailments including cancer. However, numerous novel compounds with effective MMP-8 inhibitory...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | European Journal of Medicinal Chemistry Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417424000025 |
| _version_ | 1797262784400982016 |
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| author | Sandip Kumar Baidya Suvankar Banerjee Sujay Guti Tarun Jha Nilanjan Adhikari |
| author_facet | Sandip Kumar Baidya Suvankar Banerjee Sujay Guti Tarun Jha Nilanjan Adhikari |
| author_sort | Sandip Kumar Baidya |
| collection | DOAJ |
| description | The type-II collagenase, also known as matrix metalloproteinase-8 (MMP-8) plays a vital role in a variety of physiological illnesses namely cardiovascular, musculoskeletal, renal, digestive, and respiratory ailments including cancer. However, numerous novel compounds with effective MMP-8 inhibitory activity have been created by research and academic institutions, pharmaceutical companies, and both. Sadly, despite showing promising results, these compounds have a variety of negative side effects. In this context, a number of MMP-8 inhibitors having potential inhibitory activity with different key structural features such as hydroxamates, carboxylic acid, thiol and mercaptosulfide, phosphonate, and pyrimidine-2,4,6-trione have been discussed. Additionally, various ligand-based and structure-based drug designs that have been previously conducted on a variety of MMP-8 inhibitors have been thoroughly reviewed and that can offer important information regarding the development of novel MMP-8 inhibitors in the future. Therefore, the detailed knowledge about the key structural features of the existing MMP-8 inhibitors can be found, and further with the help of drug design strategies, a novel class of collagenase inhibitors may be identified. In light of this, this work may be beneficial for researchers looking into the processes involved in developing and identifying new potential and promising MMP-8 inhibitors. |
| first_indexed | 2024-03-08T12:51:23Z |
| format | Article |
| id | doaj.art-57a2024abeb7440588f688b9fd08eb6e |
| institution | Directory Open Access Journal |
| issn | 2772-4174 |
| language | English |
| last_indexed | 2024-04-25T00:02:37Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Medicinal Chemistry Reports |
| spelling | doaj.art-57a2024abeb7440588f688b9fd08eb6e2024-03-14T06:17:04ZengElsevierEuropean Journal of Medicinal Chemistry Reports2772-41742024-04-0110100130Matrix metalloproteinase-8 (MMP-8) and its inhibitors: A minireviewSandip Kumar Baidya0Suvankar Banerjee1Sujay Guti2Tarun Jha3Nilanjan Adhikari4Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaNatural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaNatural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaCorresponding author.; Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaCorresponding author.; Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaThe type-II collagenase, also known as matrix metalloproteinase-8 (MMP-8) plays a vital role in a variety of physiological illnesses namely cardiovascular, musculoskeletal, renal, digestive, and respiratory ailments including cancer. However, numerous novel compounds with effective MMP-8 inhibitory activity have been created by research and academic institutions, pharmaceutical companies, and both. Sadly, despite showing promising results, these compounds have a variety of negative side effects. In this context, a number of MMP-8 inhibitors having potential inhibitory activity with different key structural features such as hydroxamates, carboxylic acid, thiol and mercaptosulfide, phosphonate, and pyrimidine-2,4,6-trione have been discussed. Additionally, various ligand-based and structure-based drug designs that have been previously conducted on a variety of MMP-8 inhibitors have been thoroughly reviewed and that can offer important information regarding the development of novel MMP-8 inhibitors in the future. Therefore, the detailed knowledge about the key structural features of the existing MMP-8 inhibitors can be found, and further with the help of drug design strategies, a novel class of collagenase inhibitors may be identified. In light of this, this work may be beneficial for researchers looking into the processes involved in developing and identifying new potential and promising MMP-8 inhibitors.http://www.sciencedirect.com/science/article/pii/S2772417424000025MMP-8MMP-8 inhibitorCancerLigand-based drug designStructure-based drug design |
| spellingShingle | Sandip Kumar Baidya Suvankar Banerjee Sujay Guti Tarun Jha Nilanjan Adhikari Matrix metalloproteinase-8 (MMP-8) and its inhibitors: A minireview European Journal of Medicinal Chemistry Reports MMP-8 MMP-8 inhibitor Cancer Ligand-based drug design Structure-based drug design |
| title | Matrix metalloproteinase-8 (MMP-8) and its inhibitors: A minireview |
| title_full | Matrix metalloproteinase-8 (MMP-8) and its inhibitors: A minireview |
| title_fullStr | Matrix metalloproteinase-8 (MMP-8) and its inhibitors: A minireview |
| title_full_unstemmed | Matrix metalloproteinase-8 (MMP-8) and its inhibitors: A minireview |
| title_short | Matrix metalloproteinase-8 (MMP-8) and its inhibitors: A minireview |
| title_sort | matrix metalloproteinase 8 mmp 8 and its inhibitors a minireview |
| topic | MMP-8 MMP-8 inhibitor Cancer Ligand-based drug design Structure-based drug design |
| url | http://www.sciencedirect.com/science/article/pii/S2772417424000025 |
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