Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest
Abstract Background Diabetes mellitus (DM) is associated with various cardiovascular complications, including sudden cardiac arrest (SCA). Furthermore, the severity of DM, as assessed by fasting blood glucose (FBG), is associated with the risk of SCA. However, whether long-term changes in FBG influe...
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Format: | Article |
Language: | English |
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BMC
2023-02-01
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Series: | Cardiovascular Diabetology |
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Online Access: | https://doi.org/10.1186/s12933-023-01764-0 |
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author | Yun Gi Kim Seung-Young Roh Joo Hee Jeong Hyoung Seok Lee Kyongjin Min Yun Young Choi Kyung-Do Han Jaemin Shim Jong-Il Choi Young-Hoon Kim |
author_facet | Yun Gi Kim Seung-Young Roh Joo Hee Jeong Hyoung Seok Lee Kyongjin Min Yun Young Choi Kyung-Do Han Jaemin Shim Jong-Il Choi Young-Hoon Kim |
author_sort | Yun Gi Kim |
collection | DOAJ |
description | Abstract Background Diabetes mellitus (DM) is associated with various cardiovascular complications, including sudden cardiac arrest (SCA). Furthermore, the severity of DM, as assessed by fasting blood glucose (FBG), is associated with the risk of SCA. However, whether long-term changes in FBG influence on SCA risk remains to be determined. Methods This study used sequential nationwide health screening data from 2009 and 2011. FBG was measured at each health screening, and ΔFBG was calculated as FBG in 2011–FBG in 2009. Results Overall, 2,801,153 people were analyzed, and the mean follow-up duration was 6.33 years. Compared with the euglycemic group (− 20 ≤ ΔFBG < 20), the 20 ≤ ΔFBG < 40, 40 ≤ ΔFBG < 100, and ΔFBG ≥ 100 groups had increased SCA risks of 25% (adjusted hazard ratio [HR] = 1.25; 95% confidence interval [CI] 1.16–1.35; p < 0.001), 66% (adjusted HR = 1.66; 95% CI 1.49–1.86; p < 0.001), and 2.9-fold (adjusted HR = 2.85; 95% CI 2.37–3.44; p < 0.001), respectively. The association between ΔFBG and SCA was maintained in people with DM but not in people without DM. However, sex, age, blood pressure, and presence of heart failure did not affect the association between ΔFBG and SCA. A decrease in ΔFBG over time was not associated with reduced risk of SCA: the adjusted HR was 1.11 (95% CI 0.98–1.27; p = 0.113) for the ΔFBG < –40 group and 1.12 (95% CI 1.03–1.22; p = 0.009) for the − 40 ≤ ∆FBG < − 20 group. Conclusions A long-term increase in ΔFBG can be associated with increased risk of SCA in people with DM. However, a long-term decrease in ΔFBG was not associated with reduced risk of SCA. Actions to prevent increase in FBG can have significant effects on public health in terms of SCA prevention. |
first_indexed | 2024-04-09T23:11:53Z |
format | Article |
id | doaj.art-57a3ed96375a41c0a61c401ef610678e |
institution | Directory Open Access Journal |
issn | 1475-2840 |
language | English |
last_indexed | 2024-04-09T23:11:53Z |
publishDate | 2023-02-01 |
publisher | BMC |
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series | Cardiovascular Diabetology |
spelling | doaj.art-57a3ed96375a41c0a61c401ef610678e2023-03-22T10:21:13ZengBMCCardiovascular Diabetology1475-28402023-02-0122111110.1186/s12933-023-01764-0Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrestYun Gi Kim0Seung-Young Roh1Joo Hee Jeong2Hyoung Seok Lee3Kyongjin Min4Yun Young Choi5Kyung-Do Han6Jaemin Shim7Jong-Il Choi8Young-Hoon Kim9Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Guro HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDepartment of Statistics and Actuarial Science, Soongsil UniversityDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalAbstract Background Diabetes mellitus (DM) is associated with various cardiovascular complications, including sudden cardiac arrest (SCA). Furthermore, the severity of DM, as assessed by fasting blood glucose (FBG), is associated with the risk of SCA. However, whether long-term changes in FBG influence on SCA risk remains to be determined. Methods This study used sequential nationwide health screening data from 2009 and 2011. FBG was measured at each health screening, and ΔFBG was calculated as FBG in 2011–FBG in 2009. Results Overall, 2,801,153 people were analyzed, and the mean follow-up duration was 6.33 years. Compared with the euglycemic group (− 20 ≤ ΔFBG < 20), the 20 ≤ ΔFBG < 40, 40 ≤ ΔFBG < 100, and ΔFBG ≥ 100 groups had increased SCA risks of 25% (adjusted hazard ratio [HR] = 1.25; 95% confidence interval [CI] 1.16–1.35; p < 0.001), 66% (adjusted HR = 1.66; 95% CI 1.49–1.86; p < 0.001), and 2.9-fold (adjusted HR = 2.85; 95% CI 2.37–3.44; p < 0.001), respectively. The association between ΔFBG and SCA was maintained in people with DM but not in people without DM. However, sex, age, blood pressure, and presence of heart failure did not affect the association between ΔFBG and SCA. A decrease in ΔFBG over time was not associated with reduced risk of SCA: the adjusted HR was 1.11 (95% CI 0.98–1.27; p = 0.113) for the ΔFBG < –40 group and 1.12 (95% CI 1.03–1.22; p = 0.009) for the − 40 ≤ ∆FBG < − 20 group. Conclusions A long-term increase in ΔFBG can be associated with increased risk of SCA in people with DM. However, a long-term decrease in ΔFBG was not associated with reduced risk of SCA. Actions to prevent increase in FBG can have significant effects on public health in terms of SCA prevention.https://doi.org/10.1186/s12933-023-01764-0Sudden cardiac arrestDiabetes mellitusFasting blood glucose |
spellingShingle | Yun Gi Kim Seung-Young Roh Joo Hee Jeong Hyoung Seok Lee Kyongjin Min Yun Young Choi Kyung-Do Han Jaemin Shim Jong-Il Choi Young-Hoon Kim Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest Cardiovascular Diabetology Sudden cardiac arrest Diabetes mellitus Fasting blood glucose |
title | Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest |
title_full | Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest |
title_fullStr | Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest |
title_full_unstemmed | Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest |
title_short | Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest |
title_sort | long term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest |
topic | Sudden cardiac arrest Diabetes mellitus Fasting blood glucose |
url | https://doi.org/10.1186/s12933-023-01764-0 |
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