Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest

Abstract Background Diabetes mellitus (DM) is associated with various cardiovascular complications, including sudden cardiac arrest (SCA). Furthermore, the severity of DM, as assessed by fasting blood glucose (FBG), is associated with the risk of SCA. However, whether long-term changes in FBG influe...

Full description

Bibliographic Details
Main Authors: Yun Gi Kim, Seung-Young Roh, Joo Hee Jeong, Hyoung Seok Lee, Kyongjin Min, Yun Young Choi, Kyung-Do Han, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Cardiovascular Diabetology
Subjects:
Online Access:https://doi.org/10.1186/s12933-023-01764-0
_version_ 1797865603019571200
author Yun Gi Kim
Seung-Young Roh
Joo Hee Jeong
Hyoung Seok Lee
Kyongjin Min
Yun Young Choi
Kyung-Do Han
Jaemin Shim
Jong-Il Choi
Young-Hoon Kim
author_facet Yun Gi Kim
Seung-Young Roh
Joo Hee Jeong
Hyoung Seok Lee
Kyongjin Min
Yun Young Choi
Kyung-Do Han
Jaemin Shim
Jong-Il Choi
Young-Hoon Kim
author_sort Yun Gi Kim
collection DOAJ
description Abstract Background Diabetes mellitus (DM) is associated with various cardiovascular complications, including sudden cardiac arrest (SCA). Furthermore, the severity of DM, as assessed by fasting blood glucose (FBG), is associated with the risk of SCA. However, whether long-term changes in FBG influence on SCA risk remains to be determined. Methods This study used sequential nationwide health screening data from 2009 and 2011. FBG was measured at each health screening, and ΔFBG was calculated as FBG in 2011–FBG in 2009. Results Overall, 2,801,153 people were analyzed, and the mean follow-up duration was 6.33 years. Compared with the euglycemic group (− 20 ≤ ΔFBG < 20), the 20 ≤ ΔFBG < 40, 40 ≤ ΔFBG < 100, and ΔFBG ≥ 100 groups had increased SCA risks of 25% (adjusted hazard ratio [HR] = 1.25; 95% confidence interval [CI] 1.16–1.35; p < 0.001), 66% (adjusted HR = 1.66; 95% CI 1.49–1.86; p < 0.001), and 2.9-fold (adjusted HR = 2.85; 95% CI 2.37–3.44; p < 0.001), respectively. The association between ΔFBG and SCA was maintained in people with DM but not in people without DM. However, sex, age, blood pressure, and presence of heart failure did not affect the association between ΔFBG and SCA. A decrease in ΔFBG over time was not associated with reduced risk of SCA: the adjusted HR was 1.11 (95% CI 0.98–1.27; p = 0.113) for the ΔFBG < –40 group and 1.12 (95% CI 1.03–1.22; p = 0.009) for the − 40 ≤ ∆FBG < − 20 group. Conclusions A long-term increase in ΔFBG can be associated with increased risk of SCA in people with DM. However, a long-term decrease in ΔFBG was not associated with reduced risk of SCA. Actions to prevent increase in FBG can have significant effects on public health in terms of SCA prevention.
first_indexed 2024-04-09T23:11:53Z
format Article
id doaj.art-57a3ed96375a41c0a61c401ef610678e
institution Directory Open Access Journal
issn 1475-2840
language English
last_indexed 2024-04-09T23:11:53Z
publishDate 2023-02-01
publisher BMC
record_format Article
series Cardiovascular Diabetology
spelling doaj.art-57a3ed96375a41c0a61c401ef610678e2023-03-22T10:21:13ZengBMCCardiovascular Diabetology1475-28402023-02-0122111110.1186/s12933-023-01764-0Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrestYun Gi Kim0Seung-Young Roh1Joo Hee Jeong2Hyoung Seok Lee3Kyongjin Min4Yun Young Choi5Kyung-Do Han6Jaemin Shim7Jong-Il Choi8Young-Hoon Kim9Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Guro HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDepartment of Statistics and Actuarial Science, Soongsil UniversityDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalAbstract Background Diabetes mellitus (DM) is associated with various cardiovascular complications, including sudden cardiac arrest (SCA). Furthermore, the severity of DM, as assessed by fasting blood glucose (FBG), is associated with the risk of SCA. However, whether long-term changes in FBG influence on SCA risk remains to be determined. Methods This study used sequential nationwide health screening data from 2009 and 2011. FBG was measured at each health screening, and ΔFBG was calculated as FBG in 2011–FBG in 2009. Results Overall, 2,801,153 people were analyzed, and the mean follow-up duration was 6.33 years. Compared with the euglycemic group (− 20 ≤ ΔFBG < 20), the 20 ≤ ΔFBG < 40, 40 ≤ ΔFBG < 100, and ΔFBG ≥ 100 groups had increased SCA risks of 25% (adjusted hazard ratio [HR] = 1.25; 95% confidence interval [CI] 1.16–1.35; p < 0.001), 66% (adjusted HR = 1.66; 95% CI 1.49–1.86; p < 0.001), and 2.9-fold (adjusted HR = 2.85; 95% CI 2.37–3.44; p < 0.001), respectively. The association between ΔFBG and SCA was maintained in people with DM but not in people without DM. However, sex, age, blood pressure, and presence of heart failure did not affect the association between ΔFBG and SCA. A decrease in ΔFBG over time was not associated with reduced risk of SCA: the adjusted HR was 1.11 (95% CI 0.98–1.27; p = 0.113) for the ΔFBG < –40 group and 1.12 (95% CI 1.03–1.22; p = 0.009) for the − 40 ≤ ∆FBG < − 20 group. Conclusions A long-term increase in ΔFBG can be associated with increased risk of SCA in people with DM. However, a long-term decrease in ΔFBG was not associated with reduced risk of SCA. Actions to prevent increase in FBG can have significant effects on public health in terms of SCA prevention.https://doi.org/10.1186/s12933-023-01764-0Sudden cardiac arrestDiabetes mellitusFasting blood glucose
spellingShingle Yun Gi Kim
Seung-Young Roh
Joo Hee Jeong
Hyoung Seok Lee
Kyongjin Min
Yun Young Choi
Kyung-Do Han
Jaemin Shim
Jong-Il Choi
Young-Hoon Kim
Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest
Cardiovascular Diabetology
Sudden cardiac arrest
Diabetes mellitus
Fasting blood glucose
title Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest
title_full Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest
title_fullStr Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest
title_full_unstemmed Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest
title_short Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest
title_sort long term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest
topic Sudden cardiac arrest
Diabetes mellitus
Fasting blood glucose
url https://doi.org/10.1186/s12933-023-01764-0
work_keys_str_mv AT yungikim longtermincreaseinfastingbloodglucoseisassociatedwithincreasedriskofsuddencardiacarrest
AT seungyoungroh longtermincreaseinfastingbloodglucoseisassociatedwithincreasedriskofsuddencardiacarrest
AT jooheejeong longtermincreaseinfastingbloodglucoseisassociatedwithincreasedriskofsuddencardiacarrest
AT hyoungseoklee longtermincreaseinfastingbloodglucoseisassociatedwithincreasedriskofsuddencardiacarrest
AT kyongjinmin longtermincreaseinfastingbloodglucoseisassociatedwithincreasedriskofsuddencardiacarrest
AT yunyoungchoi longtermincreaseinfastingbloodglucoseisassociatedwithincreasedriskofsuddencardiacarrest
AT kyungdohan longtermincreaseinfastingbloodglucoseisassociatedwithincreasedriskofsuddencardiacarrest
AT jaeminshim longtermincreaseinfastingbloodglucoseisassociatedwithincreasedriskofsuddencardiacarrest
AT jongilchoi longtermincreaseinfastingbloodglucoseisassociatedwithincreasedriskofsuddencardiacarrest
AT younghoonkim longtermincreaseinfastingbloodglucoseisassociatedwithincreasedriskofsuddencardiacarrest