Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)-<i>N</i>-(2-hydroxyethyl)-<i>N</i>-Phenyl-Benzeneacetamide that Reduces Melanin Synthesis by Inhibiting Tyrosinase Activity Independently of Epigenetic Mechanisms

Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)-<i>N</i>-(2-hydroxyethyl)-<i>N</i>-Phenyl-Benzeneacetamide that Reduces Melanin Synthesis by Inhibiting Tyrosinase Activity Independently of Epigenetic Mechanisms

The aim of this study was to identify novel antimelanogenic drugs from an epigenetic screening library containing various modulators targeting DNA methyltransferases, histone deacetylases, and other related enzymes/proteins. Of 141 drugs tested, K8 (4-((hydroxyamino)carbonyl)-<i>N</i>-(2...

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Bibliographic Details
Main Authors: Hyerim Song, Yun Jeong Hwang, Jae Won Ha, Yong Chool Boo
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
melanin
epigenetic screening library
antimelanogenic drug
tyrosinase
pigmentation
4-((hydroxyamino)carbonyl)-<i>N</i>-(2-hydroxyethyl)-<i>N</i>-phenyl-benzeneacetamide
Online Access:https://www.mdpi.com/1422-0067/21/13/4589

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https://www.mdpi.com/1422-0067/21/13/4589

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