Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)-<i>N</i>-(2-hydroxyethyl)-<i>N</i>-Phenyl-Benzeneacetamide that Reduces Melanin Synthesis by Inhibiting Tyrosinase Activity Independently of Epigenetic Mechanisms
The aim of this study was to identify novel antimelanogenic drugs from an epigenetic screening library containing various modulators targeting DNA methyltransferases, histone deacetylases, and other related enzymes/proteins. Of 141 drugs tested, K8 (4-((hydroxyamino)carbonyl)-<i>N</i>-(2...
Main Authors: | Hyerim Song, Yun Jeong Hwang, Jae Won Ha, Yong Chool Boo |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/13/4589 |
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