Genetic and diet effects on <it>Ppar-α </it>and <it>Ppar-γ </it>signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity
<p>Abstract</p> <p>Background</p> <p>The Berlin Fat Mouse Inbred (BFMI) line is a new mouse model for obesity, which was long-term selected for high fatness. Peroxisome proliferator-activated receptors (PPARs) are involved in the control of energy homeostasis, nutrient...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-09-01
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| Series: | Lipids in Health and Disease |
| Online Access: | http://www.lipidworld.com/content/9/1/99 |
| _version_ | 1818777219941531648 |
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| author | Wagener Asja Goessling Helge F Schmitt Armin O Mauel Susanne Gruber Achim D Reinhardt Richard Brockmann Gudrun A |
| author_facet | Wagener Asja Goessling Helge F Schmitt Armin O Mauel Susanne Gruber Achim D Reinhardt Richard Brockmann Gudrun A |
| author_sort | Wagener Asja |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The Berlin Fat Mouse Inbred (BFMI) line is a new mouse model for obesity, which was long-term selected for high fatness. Peroxisome proliferator-activated receptors (PPARs) are involved in the control of energy homeostasis, nutrient metabolism and cell proliferation. Here, we studied the expression patterns of the different <it>Ppar </it>genes and the genes in the PPAR pathway in the BFMI line in comparison to physiological changes.</p> <p>Results</p> <p>At the age of 10 weeks, the BFMI mice exhibited marked obesity with enlarged adipocytes and high serum triglycerides concentrations in comparison to the often used mouse line C57BL/6 (B6). Between these two lines, gene expression analyses revealed differentially expressed genes belonging to the PPAR pathway, in particular genes of the lipogenesis and the fatty acid transport.</p> <p>Conclusion</p> <p>Surprisingly, the <it>Ppar-α </it>gene expression was up-regulated in liver and <it>Ppar-γ </it>gene expression was down-regulated in the white adipose tissue, indicating the activation of a mechanism that counteracts the rise of obesity.</p> |
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| format | Article |
| id | doaj.art-57a5638f9e6e4b2bbc86320131f8e55c |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-18T11:25:21Z |
| publishDate | 2010-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-57a5638f9e6e4b2bbc86320131f8e55c2022-12-21T21:09:42ZengBMCLipids in Health and Disease1476-511X2010-09-01919910.1186/1476-511X-9-99Genetic and diet effects on <it>Ppar-α </it>and <it>Ppar-γ </it>signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesityWagener AsjaGoessling Helge FSchmitt Armin OMauel SusanneGruber Achim DReinhardt RichardBrockmann Gudrun A<p>Abstract</p> <p>Background</p> <p>The Berlin Fat Mouse Inbred (BFMI) line is a new mouse model for obesity, which was long-term selected for high fatness. Peroxisome proliferator-activated receptors (PPARs) are involved in the control of energy homeostasis, nutrient metabolism and cell proliferation. Here, we studied the expression patterns of the different <it>Ppar </it>genes and the genes in the PPAR pathway in the BFMI line in comparison to physiological changes.</p> <p>Results</p> <p>At the age of 10 weeks, the BFMI mice exhibited marked obesity with enlarged adipocytes and high serum triglycerides concentrations in comparison to the often used mouse line C57BL/6 (B6). Between these two lines, gene expression analyses revealed differentially expressed genes belonging to the PPAR pathway, in particular genes of the lipogenesis and the fatty acid transport.</p> <p>Conclusion</p> <p>Surprisingly, the <it>Ppar-α </it>gene expression was up-regulated in liver and <it>Ppar-γ </it>gene expression was down-regulated in the white adipose tissue, indicating the activation of a mechanism that counteracts the rise of obesity.</p>http://www.lipidworld.com/content/9/1/99 |
| spellingShingle | Wagener Asja Goessling Helge F Schmitt Armin O Mauel Susanne Gruber Achim D Reinhardt Richard Brockmann Gudrun A Genetic and diet effects on <it>Ppar-α </it>and <it>Ppar-γ </it>signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity Lipids in Health and Disease |
| title | Genetic and diet effects on <it>Ppar-α </it>and <it>Ppar-γ </it>signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity |
| title_full | Genetic and diet effects on <it>Ppar-α </it>and <it>Ppar-γ </it>signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity |
| title_fullStr | Genetic and diet effects on <it>Ppar-α </it>and <it>Ppar-γ </it>signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity |
| title_full_unstemmed | Genetic and diet effects on <it>Ppar-α </it>and <it>Ppar-γ </it>signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity |
| title_short | Genetic and diet effects on <it>Ppar-α </it>and <it>Ppar-γ </it>signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity |
| title_sort | genetic and diet effects on it ppar α it and it ppar γ it signaling pathways in the berlin fat mouse inbred line with genetic predisposition for obesity |
| url | http://www.lipidworld.com/content/9/1/99 |
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