Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides

Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides

Neoantigen formation due to the interaction of drug molecules with human leukocyte antigen (HLA)-peptide complexes can lead to severe hypersensitivity reactions. Flucloxacillin (FLX), a β-lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune...

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Bibliographic Details
Main Authors: Montserrat Puig, Suryatheja Ananthula, Ramesh Venna, Swamy Kumar Polumuri, Elliot Mattson, Lacey M. Walker, Marco Cardone, Mayumi Takahashi, Shan Su, Lisa F. Boyd, Kannan Natarajan, Galina Abdoulaeva, Wells W. Wu, Gregory Roderiquez, William H. Hildebrand, Serge L. Beaucage, Zhihua Li, David H. Margulies, Michael A. Norcross
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
flucloxacillin
HLA-B*57:01
drug hypersensitivity
hapten
immunogenicity
transgenic mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.629399/full

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