High neutrophil counts before endovascular treatment for acute basilar artery occlusion predict worse outcomes
Background and purposeIschemic stroke is related to inflammation. We investigated leukocyte counts, neutrophil counts, and NLR (neutrophil-to-lymphocyte ratio) to explore their prognostic potential and determine if high neutrophil counts before endovascular treatment (EVT) in patients with acute bas...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.978740/full |
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| author | Maofan Liao Fengli Li Jinrong Hu Jie Yang Deping Wu Dongjing Xie Jiaxing Song Jiacheng Huang Yan Tian Weidong Luo Chengsong Yue Shuai Liu Weilin Kong Li Huang Wenjie Zi Fangfei Li |
| author_facet | Maofan Liao Fengli Li Jinrong Hu Jie Yang Deping Wu Dongjing Xie Jiaxing Song Jiacheng Huang Yan Tian Weidong Luo Chengsong Yue Shuai Liu Weilin Kong Li Huang Wenjie Zi Fangfei Li |
| author_sort | Maofan Liao |
| collection | DOAJ |
| description | Background and purposeIschemic stroke is related to inflammation. We investigated leukocyte counts, neutrophil counts, and NLR (neutrophil-to-lymphocyte ratio) to explore their prognostic potential and determine if high neutrophil counts before endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO) are associated with worse outcomes at 90 days post-EVT.MethodsLeukocyte and neutrophil counts and NLR were determined in eligible patients from the Acute Basilar Artery Occlusion Study (BASILAR). Patients were divided into four groups according to leukocyte and neutrophil counts and NLR quartiles. The primary outcome was a favorable outcome based on the modified Rankin Scale (mRS: 0–3). The secondary outcome was functional independence (mRS 0–2). The safety outcome was mortality, and an unfavorable outcome was mRS 4–6. Successful reperfusion was mTICI (modified Thrombolysis in Cerebral Infarction) of 2b or 3. All the data were collected within 90 days after EVT.ResultsWe enrolled 586 patients in the study. The leukocyte and neutrophil counts and NLR were significantly associated with clinical outcomes in all patients though no effects were seen in some intervals. Of these three parameters, the neutrophil count had the most significant impact, negatively affecting the outcome. The findings were similar in patients who were successfully recanalized.ConclusionHigher neutrophil counts predicted worse clinical outcomes 90 days after EVT. This finding supports the deleterious role of inflammation in patients with acute BAO despite EVT or successful recanalization. |
| first_indexed | 2024-04-13T17:57:51Z |
| format | Article |
| id | doaj.art-57a6741187d04013a7387e92b8aec3bc |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T17:57:51Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-57a6741187d04013a7387e92b8aec3bc2022-12-22T02:36:24ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-09-011410.3389/fnagi.2022.978740978740High neutrophil counts before endovascular treatment for acute basilar artery occlusion predict worse outcomesMaofan LiaoFengli LiJinrong HuJie YangDeping WuDongjing XieJiaxing SongJiacheng HuangYan TianWeidong LuoChengsong YueShuai LiuWeilin KongLi HuangWenjie ZiFangfei LiBackground and purposeIschemic stroke is related to inflammation. We investigated leukocyte counts, neutrophil counts, and NLR (neutrophil-to-lymphocyte ratio) to explore their prognostic potential and determine if high neutrophil counts before endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO) are associated with worse outcomes at 90 days post-EVT.MethodsLeukocyte and neutrophil counts and NLR were determined in eligible patients from the Acute Basilar Artery Occlusion Study (BASILAR). Patients were divided into four groups according to leukocyte and neutrophil counts and NLR quartiles. The primary outcome was a favorable outcome based on the modified Rankin Scale (mRS: 0–3). The secondary outcome was functional independence (mRS 0–2). The safety outcome was mortality, and an unfavorable outcome was mRS 4–6. Successful reperfusion was mTICI (modified Thrombolysis in Cerebral Infarction) of 2b or 3. All the data were collected within 90 days after EVT.ResultsWe enrolled 586 patients in the study. The leukocyte and neutrophil counts and NLR were significantly associated with clinical outcomes in all patients though no effects were seen in some intervals. Of these three parameters, the neutrophil count had the most significant impact, negatively affecting the outcome. The findings were similar in patients who were successfully recanalized.ConclusionHigher neutrophil counts predicted worse clinical outcomes 90 days after EVT. This finding supports the deleterious role of inflammation in patients with acute BAO despite EVT or successful recanalization.https://www.frontiersin.org/articles/10.3389/fnagi.2022.978740/fullleukocyteneutrophilNLRacute basilar artery occlusionprognosis |
| spellingShingle | Maofan Liao Fengli Li Jinrong Hu Jie Yang Deping Wu Dongjing Xie Jiaxing Song Jiacheng Huang Yan Tian Weidong Luo Chengsong Yue Shuai Liu Weilin Kong Li Huang Wenjie Zi Fangfei Li High neutrophil counts before endovascular treatment for acute basilar artery occlusion predict worse outcomes Frontiers in Aging Neuroscience leukocyte neutrophil NLR acute basilar artery occlusion prognosis |
| title | High neutrophil counts before endovascular treatment for acute basilar artery occlusion predict worse outcomes |
| title_full | High neutrophil counts before endovascular treatment for acute basilar artery occlusion predict worse outcomes |
| title_fullStr | High neutrophil counts before endovascular treatment for acute basilar artery occlusion predict worse outcomes |
| title_full_unstemmed | High neutrophil counts before endovascular treatment for acute basilar artery occlusion predict worse outcomes |
| title_short | High neutrophil counts before endovascular treatment for acute basilar artery occlusion predict worse outcomes |
| title_sort | high neutrophil counts before endovascular treatment for acute basilar artery occlusion predict worse outcomes |
| topic | leukocyte neutrophil NLR acute basilar artery occlusion prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.978740/full |
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