Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease

Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease

Structural and molecular myelination deficits represent early pathological features of Huntington disease (HD). Recent evidence from germ-free (GF) animals suggests a role for microbiota-gut-brain bidirectional communication in the regulation of myelination. In this study, we aimed to investigate th...

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Bibliographic Details
Main Authors: Carola I. Radulescu, Marta Garcia-Miralles, Harwin Sidik, Costanza Ferrari Bardile, Nur Amirah Binte Mohammad Yusof, Hae Ung Lee, Eliza Xin Pei Ho, Collins Wenhan Chu, Emma Layton, Donovan Low, Paola Florez De Sessions, Sven Pettersson, Florent Ginhoux, Mahmoud A. Pouladi
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Huntington disease
BACHD
White matter
Myelination
Oligodendrocytes
Germ-free
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118305515

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