Effectiveness and Safety of Ginkgo biloba, Vinpocetine and Piracetam as a Single Agent and Fixed Dose Combination in Patients with Subjective Tinnitus
Introduction: Owing to the lack of any standard treatment, subjective tinnitus can be debilitating, manifesting a varied population response to tinnitus management. There is, therefore, an unmet need to optimise the existing treatment options and generate data to help physicians provide the best...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2021-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/14589/48182_CE[Ra]_F(Sh)_PF1(AG_SL)_PFA(SL)_PB(AG_SHU)_PN(SHU).pdf |
| _version_ | 1798033163948130304 |
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| author | Paul Mathai Anu Chandran Sourav Das |
| author_facet | Paul Mathai Anu Chandran Sourav Das |
| author_sort | Paul Mathai |
| collection | DOAJ |
| description | Introduction: Owing to the lack of any standard treatment,
subjective tinnitus can be debilitating, manifesting a varied
population response to tinnitus management. There is, therefore,
an unmet need to optimise the existing treatment options and
generate data to help physicians provide the best possible care
for individual patients.
Aim: To compare the effectiveness and safety of Ginkgo biloba,
vinpocetine, and piracetam as a single agent and their Fixed
Dose Combination (FDC) in patients with subjective tinnitus.
Materials and Methods: Patients with complaints of subjective
tinnitus were enrolled in this longitudinal cohort, single centre
study which was conducted at Outpatient Clinic of the ENT
Department of Justice KS Hegde Charitable Hospital, Karnataka,
India. Patients received one of the five treatments, oral route,
three times a day, {group 1: Ginkgo biloba (40 mg); group 2:
vinpocetine (5 mg); group 3: piracetam (400 mg); group 4: FDC
of Ginkgo biloba (60 mg) and piracetam (400 mg); group 5: FDC
of Ginkgo biloba (60 mg), piracetam (800 mg) and vinpocetine
(5 mg)} and were followed-up for six weeks using a modified
version of Tinnitus Handicap Inventory (THI) and Visual Analogue
Scale (VAS), before and after the treatment. Data for safety were
also recorded. The association between each attribute and the
presence of tinnitus was assessed through chi-square tests.
Results: A total of 130 out of 149 enrolled patients completed
the study. All the groups showed significant improvement in the
severity of symptoms at the end of six weeks as assessed by
the modified THI and VAS scores. The improvement was found
to be better in group 5 than in other groups, which was evident
from the percentage improvement at the end of the treatment
compared to other groups. No adverse drug reactions were
associated with any of the treatment groups.
Conclusion: Though all the drugs were found to be effective
and safe in reducing the intensity of subjective tinnitus, FDC
of Ginkgo biloba-piracetam-vinpocetine may be considered a
better alternative than Ginkgo biloba-piracetam combination
and Ginkgo biloba, piracetam, or vinpocetine as single agents. |
| first_indexed | 2024-04-11T20:24:49Z |
| format | Article |
| id | doaj.art-57a9d6d6c97c4e20aedd1b8b6a17383b |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-11T20:24:49Z |
| publishDate | 2021-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-57a9d6d6c97c4e20aedd1b8b6a17383b2022-12-22T04:04:41ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-02-01152MC01MC0510.7860/JCDR/2021/48182.14589Effectiveness and Safety of Ginkgo biloba, Vinpocetine and Piracetam as a Single Agent and Fixed Dose Combination in Patients with Subjective TinnitusPaul Mathai0Anu Chandran1Sourav Das2Assistant Professor, Department of Pharmacology, Malabar Medical College, Modakkallur, Calicut, Kerala, India.Assistant Professor, Department of Pharmacology, Malabar Medical College, Modakkallur, Calicut, Kerala, India.Physician, Department of Emergency, Amina Hospital, Ajman, United Arab Emirates.Introduction: Owing to the lack of any standard treatment, subjective tinnitus can be debilitating, manifesting a varied population response to tinnitus management. There is, therefore, an unmet need to optimise the existing treatment options and generate data to help physicians provide the best possible care for individual patients. Aim: To compare the effectiveness and safety of Ginkgo biloba, vinpocetine, and piracetam as a single agent and their Fixed Dose Combination (FDC) in patients with subjective tinnitus. Materials and Methods: Patients with complaints of subjective tinnitus were enrolled in this longitudinal cohort, single centre study which was conducted at Outpatient Clinic of the ENT Department of Justice KS Hegde Charitable Hospital, Karnataka, India. Patients received one of the five treatments, oral route, three times a day, {group 1: Ginkgo biloba (40 mg); group 2: vinpocetine (5 mg); group 3: piracetam (400 mg); group 4: FDC of Ginkgo biloba (60 mg) and piracetam (400 mg); group 5: FDC of Ginkgo biloba (60 mg), piracetam (800 mg) and vinpocetine (5 mg)} and were followed-up for six weeks using a modified version of Tinnitus Handicap Inventory (THI) and Visual Analogue Scale (VAS), before and after the treatment. Data for safety were also recorded. The association between each attribute and the presence of tinnitus was assessed through chi-square tests. Results: A total of 130 out of 149 enrolled patients completed the study. All the groups showed significant improvement in the severity of symptoms at the end of six weeks as assessed by the modified THI and VAS scores. The improvement was found to be better in group 5 than in other groups, which was evident from the percentage improvement at the end of the treatment compared to other groups. No adverse drug reactions were associated with any of the treatment groups. Conclusion: Though all the drugs were found to be effective and safe in reducing the intensity of subjective tinnitus, FDC of Ginkgo biloba-piracetam-vinpocetine may be considered a better alternative than Ginkgo biloba-piracetam combination and Ginkgo biloba, piracetam, or vinpocetine as single agents.https://www.jcdr.net/articles/PDF/14589/48182_CE[Ra]_F(Sh)_PF1(AG_SL)_PFA(SL)_PB(AG_SHU)_PN(SHU).pdfexternal acoustic stimulustinnitus handicap inventoryvisual analogue scale |
| spellingShingle | Paul Mathai Anu Chandran Sourav Das Effectiveness and Safety of Ginkgo biloba, Vinpocetine and Piracetam as a Single Agent and Fixed Dose Combination in Patients with Subjective Tinnitus Journal of Clinical and Diagnostic Research external acoustic stimulus tinnitus handicap inventory visual analogue scale |
| title | Effectiveness and Safety of Ginkgo biloba, Vinpocetine and Piracetam as a Single Agent and Fixed Dose Combination in Patients with Subjective Tinnitus |
| title_full | Effectiveness and Safety of Ginkgo biloba, Vinpocetine and Piracetam as a Single Agent and Fixed Dose Combination in Patients with Subjective Tinnitus |
| title_fullStr | Effectiveness and Safety of Ginkgo biloba, Vinpocetine and Piracetam as a Single Agent and Fixed Dose Combination in Patients with Subjective Tinnitus |
| title_full_unstemmed | Effectiveness and Safety of Ginkgo biloba, Vinpocetine and Piracetam as a Single Agent and Fixed Dose Combination in Patients with Subjective Tinnitus |
| title_short | Effectiveness and Safety of Ginkgo biloba, Vinpocetine and Piracetam as a Single Agent and Fixed Dose Combination in Patients with Subjective Tinnitus |
| title_sort | effectiveness and safety of ginkgo biloba vinpocetine and piracetam as a single agent and fixed dose combination in patients with subjective tinnitus |
| topic | external acoustic stimulus tinnitus handicap inventory visual analogue scale |
| url | https://www.jcdr.net/articles/PDF/14589/48182_CE[Ra]_F(Sh)_PF1(AG_SL)_PFA(SL)_PB(AG_SHU)_PN(SHU).pdf |
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