Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China
Objective: Prolylcarboxypeptidase (PRCP) is both involved in the Kallikrein-Kinin system (KKS) and renin-angiotensin-aldosterone system (RAAS). This study aimed to determine the genetic impact of PRCP gene polymorphisms on essential hypertension (EH) in an isolated population from a remote region of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2020-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320320981316 |
| _version_ | 1797282077613228032 |
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| author | Yanrui Wu Xingming Pan Xiaoxiao Jin |
| author_facet | Yanrui Wu Xingming Pan Xiaoxiao Jin |
| author_sort | Yanrui Wu |
| collection | DOAJ |
| description | Objective: Prolylcarboxypeptidase (PRCP) is both involved in the Kallikrein-Kinin system (KKS) and renin-angiotensin-aldosterone system (RAAS). This study aimed to determine the genetic impact of PRCP gene polymorphisms on essential hypertension (EH) in an isolated population from a remote region of China. Methods: A haplotype-based study was investigated in 346 EH patients and 346 normal subjects and all samples were Hani minority residents in Southwest China. A total of 11 tag single nucleotide polymorphisms (SNPs) in PRCP gene were tested by polymerase chain reaction-restriction fragment length polymorphism method. Results: Single site analysis found that PRCP gene 3′UTR SNP rs3750931 was associated with EH. The minor allele G of rs3750931 was more prevalent in the EH patients compared to control subjects after Bonferroni correction ( p < 0.05). Moreover, the rs3750931 G allele carriers showed higher average blood pressure (BP) level among the subjects. The H2 (GAGCACTAACA) haplotype without rs3750931 G allele showed the protective effect for EH (OR = 0.68, 95 CI 0.54–0.85, p = 0.001). Conclusion: The present study indicated PRCP gene rs3750931 was associated with the risk of EH. This SNP G allele could be considered as one of risk markers for EH in Hani population. |
| first_indexed | 2024-03-07T17:06:47Z |
| format | Article |
| id | doaj.art-57aaab82ce2a412592abf18527a24947 |
| institution | Directory Open Access Journal |
| issn | 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:06:47Z |
| publishDate | 2020-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-57aaab82ce2a412592abf18527a249472024-03-03T02:32:41ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1752-89762020-12-012110.1177/1470320320981316Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of ChinaYanrui Wu0Xingming Pan1Xiaoxiao Jin2School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan Province, P. R. ChinaHuman Resources Department of Kunming Medical University, Kunming, Yunnan Province, P. R. ChinaSchool of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan Province, P. R. ChinaObjective: Prolylcarboxypeptidase (PRCP) is both involved in the Kallikrein-Kinin system (KKS) and renin-angiotensin-aldosterone system (RAAS). This study aimed to determine the genetic impact of PRCP gene polymorphisms on essential hypertension (EH) in an isolated population from a remote region of China. Methods: A haplotype-based study was investigated in 346 EH patients and 346 normal subjects and all samples were Hani minority residents in Southwest China. A total of 11 tag single nucleotide polymorphisms (SNPs) in PRCP gene were tested by polymerase chain reaction-restriction fragment length polymorphism method. Results: Single site analysis found that PRCP gene 3′UTR SNP rs3750931 was associated with EH. The minor allele G of rs3750931 was more prevalent in the EH patients compared to control subjects after Bonferroni correction ( p < 0.05). Moreover, the rs3750931 G allele carriers showed higher average blood pressure (BP) level among the subjects. The H2 (GAGCACTAACA) haplotype without rs3750931 G allele showed the protective effect for EH (OR = 0.68, 95 CI 0.54–0.85, p = 0.001). Conclusion: The present study indicated PRCP gene rs3750931 was associated with the risk of EH. This SNP G allele could be considered as one of risk markers for EH in Hani population.https://doi.org/10.1177/1470320320981316 |
| spellingShingle | Yanrui Wu Xingming Pan Xiaoxiao Jin Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China Journal of the Renin-Angiotensin-Aldosterone System |
| title | Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China |
| title_full | Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China |
| title_fullStr | Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China |
| title_full_unstemmed | Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China |
| title_short | Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China |
| title_sort | haplotype based association study between prcp gene polymorphisms and essential hypertension in hani minority group from a remote region of china |
| url | https://doi.org/10.1177/1470320320981316 |
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