Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern Siberia
Abstract Background N-acetyltransferase 2 plays a crucial role in the metabolism of a wide range of xenobiotics, including many drugs, carcinogens, and other chemicals in the human environment. The article presents for the first time data on the frequency of two important “slow” variants of NAT2 gen...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | BMC Genetics |
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| Online Access: | http://link.springer.com/article/10.1186/s12863-020-00909-4 |
| _version_ | 1817983140440834048 |
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| author | Roza Pavlovna Tiis Ludmila Pavlovna Osipova Daria Veniaminovna Lichman Elena Nikolaevna Voronina Maxim Leonidovich Filipenko |
| author_facet | Roza Pavlovna Tiis Ludmila Pavlovna Osipova Daria Veniaminovna Lichman Elena Nikolaevna Voronina Maxim Leonidovich Filipenko |
| author_sort | Roza Pavlovna Tiis |
| collection | DOAJ |
| description | Abstract Background N-acetyltransferase 2 plays a crucial role in the metabolism of a wide range of xenobiotics, including many drugs, carcinogens, and other chemicals in the human environment. The article presents for the first time data on the frequency of two important “slow” variants of NAT2 gene (NAT2*5, rs1801280 and NAT2*7, rs1799931), which significantly affect the rate of xenobiotics acetylation, among representatives of indigenous populations of Forest and Tundra Nenets in Northern Siberia. The aim of this study was to identify the frequencies of these variants and compare them with frequencies in other ethnic populations. Results NAT2*5 (T341C) genotyping revealed frequencies of 28,0% and 38,6% for Tundra and Forest Nenets, respectively. The frequencies of NAT2*7 (G857A) variant were 9,8% and 8,2% for Tundra and Forest Nenets, respectively. Polymorphic variants frequencies for Nenets are intermediate between those in populations of Europeans and Asians. These results can probably be explained by the presence of both European and Asian components in Nenets gene pools. Conclusions The results of this study expand the knowledge of NAT2 polymorphism in world populations. These data may also help assess the genetic predisposition of Nenets to multifactorial diseases associated with polymorphism in the NAT2 gene and, in general, contribute to the development of personalized medicine in reference to native people of Siberia. |
| first_indexed | 2024-04-13T23:29:44Z |
| format | Article |
| id | doaj.art-57aad86877244246933f939b738ee691 |
| institution | Directory Open Access Journal |
| issn | 1471-2156 |
| language | English |
| last_indexed | 2024-04-13T23:29:44Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genetics |
| spelling | doaj.art-57aad86877244246933f939b738ee6912022-12-22T02:24:57ZengBMCBMC Genetics1471-21562020-10-0121S11710.1186/s12863-020-00909-4Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern SiberiaRoza Pavlovna Tiis0Ludmila Pavlovna Osipova1Daria Veniaminovna Lichman2Elena Nikolaevna Voronina3Maxim Leonidovich Filipenko4Institute of Cytology and Genetics SB RASInstitute of Cytology and Genetics SB RASInstitute of Cytology and Genetics SB RASNovosibirsk State University, Russian FederationNovosibirsk State University, Russian FederationAbstract Background N-acetyltransferase 2 plays a crucial role in the metabolism of a wide range of xenobiotics, including many drugs, carcinogens, and other chemicals in the human environment. The article presents for the first time data on the frequency of two important “slow” variants of NAT2 gene (NAT2*5, rs1801280 and NAT2*7, rs1799931), which significantly affect the rate of xenobiotics acetylation, among representatives of indigenous populations of Forest and Tundra Nenets in Northern Siberia. The aim of this study was to identify the frequencies of these variants and compare them with frequencies in other ethnic populations. Results NAT2*5 (T341C) genotyping revealed frequencies of 28,0% and 38,6% for Tundra and Forest Nenets, respectively. The frequencies of NAT2*7 (G857A) variant were 9,8% and 8,2% for Tundra and Forest Nenets, respectively. Polymorphic variants frequencies for Nenets are intermediate between those in populations of Europeans and Asians. These results can probably be explained by the presence of both European and Asian components in Nenets gene pools. Conclusions The results of this study expand the knowledge of NAT2 polymorphism in world populations. These data may also help assess the genetic predisposition of Nenets to multifactorial diseases associated with polymorphism in the NAT2 gene and, in general, contribute to the development of personalized medicine in reference to native people of Siberia.http://link.springer.com/article/10.1186/s12863-020-00909-4XenobioticsNAT2 geneNAT2*5, rs1801280NAT2*7, rs1799931Forest and Tundra NenetsNorthern Siberia |
| spellingShingle | Roza Pavlovna Tiis Ludmila Pavlovna Osipova Daria Veniaminovna Lichman Elena Nikolaevna Voronina Maxim Leonidovich Filipenko Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern Siberia BMC Genetics Xenobiotics NAT2 gene NAT2*5, rs1801280 NAT2*7, rs1799931 Forest and Tundra Nenets Northern Siberia |
| title | Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern Siberia |
| title_full | Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern Siberia |
| title_fullStr | Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern Siberia |
| title_full_unstemmed | Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern Siberia |
| title_short | Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern Siberia |
| title_sort | studying polymorphic variants of the nat2 gene nat2 5 and nat2 7 in nenets populations of northern siberia |
| topic | Xenobiotics NAT2 gene NAT2*5, rs1801280 NAT2*7, rs1799931 Forest and Tundra Nenets Northern Siberia |
| url | http://link.springer.com/article/10.1186/s12863-020-00909-4 |
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