Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study
Xin Li,* Hui-Yao Li,* Zi-Wei Yu, Yi-Tong Zhang, Xue-Wei Tong, Xin-Yuan Gao The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin-Yuan GaoDepartment...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-12-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/association-among-lipid-accumulation-product-chinese-visceral-obesity--peer-reviewed-fulltext-article-DMSO |
| _version_ | 1827884892620324864 |
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| author | Li X Li HY Yu ZW Zhang YT Tong XW Gao XY |
| author_facet | Li X Li HY Yu ZW Zhang YT Tong XW Gao XY |
| author_sort | Li X |
| collection | DOAJ |
| description | Xin Li,* Hui-Yao Li,* Zi-Wei Yu, Yi-Tong Zhang, Xue-Wei Tong, Xin-Yuan Gao The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin-Yuan GaoDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of ChinaTel +86 13904517001Email 15369337970@163.comBackground and Aim: Obesity often coexists with diabetes, especially abdominal obesity, recognized as a risk factor for diabetic complications. Diabetic retinopathy (DR), as one of the most common microvascular complications of diabetes, may be associated with these indices. Lipid accumulation product (LAP) and Chinese visceral obesity index (CVAI) are novel visceral obesity indicators, which have been proven to be an influential factor predicting type 2 diabetes (T2DM). However, the correlation among LAP, CVAI, and DR still lacks systematic research in T2DM. The study aimed to explore the relationship among LAP, CVAI levels in different DR stages of T2DM patients and the diagnostic efficacy of LAP and CVAI for DR.Methods: A total of 263 participants were recruited in this cross-sectional study. We enrolled 169 patients with T2DM, divided into the non-DR group (NDR, n = 61), non-proliferative DR group (NPDR, n = 55), and proliferative DR group (PDR, n = 53). And we also enrolled 94 healthy control participants. We collected demographic, anthropometric, and biochemical data on each subject. LAP and CVAI are calculated according to different formulas for men and women.Results: Compared with the control group, LAP and CVAI were significantly higher (P < 0.05). After adjusting for confounding factors, LAP (OR: 1.029, 95CI%: 1.010– 1.049, P < 0.05), WC (OR: 1.073, 95CI%: 1.009– 1.141, P < 0.05) and CVAI (OR: 1.017, 95CI%: 1.000– 1.033, P < 0.05) were all associated with an increased risk of DR. Furthermore, increased LAP (OR: 1.020, 95% CI: 0.100– 0.290) is associated with DR severity (P < 0.001). Moreover, the LAP had the most significant area under the receiver operating characteristics (ROC) curve (AUC) (AUC = 0.728, 95% CI: 0.653– 0.804).Conclusion: A high LAP is associated with an increased risk of DR in T2DM patients, and the LAP index appears to be a good predictor of DR risk and severity in patients with T2DM, compared with BMI, WC, and CVAI.Keywords: lipid accumulation product, LAP, Chinese visceral obesity index, CVAI, diabetic retinopathy, DR, abdominal/visceral obesity |
| first_indexed | 2024-03-12T19:36:22Z |
| format | Article |
| id | doaj.art-57aba7c9d2e944cf90f02b5995aadfd8 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-12T19:36:22Z |
| publishDate | 2021-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-57aba7c9d2e944cf90f02b5995aadfd82023-08-02T04:07:44ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072021-12-01Volume 144971497971891Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional StudyLi XLi HYYu ZWZhang YTTong XWGao XYXin Li,* Hui-Yao Li,* Zi-Wei Yu, Yi-Tong Zhang, Xue-Wei Tong, Xin-Yuan Gao The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin-Yuan GaoDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of ChinaTel +86 13904517001Email 15369337970@163.comBackground and Aim: Obesity often coexists with diabetes, especially abdominal obesity, recognized as a risk factor for diabetic complications. Diabetic retinopathy (DR), as one of the most common microvascular complications of diabetes, may be associated with these indices. Lipid accumulation product (LAP) and Chinese visceral obesity index (CVAI) are novel visceral obesity indicators, which have been proven to be an influential factor predicting type 2 diabetes (T2DM). However, the correlation among LAP, CVAI, and DR still lacks systematic research in T2DM. The study aimed to explore the relationship among LAP, CVAI levels in different DR stages of T2DM patients and the diagnostic efficacy of LAP and CVAI for DR.Methods: A total of 263 participants were recruited in this cross-sectional study. We enrolled 169 patients with T2DM, divided into the non-DR group (NDR, n = 61), non-proliferative DR group (NPDR, n = 55), and proliferative DR group (PDR, n = 53). And we also enrolled 94 healthy control participants. We collected demographic, anthropometric, and biochemical data on each subject. LAP and CVAI are calculated according to different formulas for men and women.Results: Compared with the control group, LAP and CVAI were significantly higher (P < 0.05). After adjusting for confounding factors, LAP (OR: 1.029, 95CI%: 1.010– 1.049, P < 0.05), WC (OR: 1.073, 95CI%: 1.009– 1.141, P < 0.05) and CVAI (OR: 1.017, 95CI%: 1.000– 1.033, P < 0.05) were all associated with an increased risk of DR. Furthermore, increased LAP (OR: 1.020, 95% CI: 0.100– 0.290) is associated with DR severity (P < 0.001). Moreover, the LAP had the most significant area under the receiver operating characteristics (ROC) curve (AUC) (AUC = 0.728, 95% CI: 0.653– 0.804).Conclusion: A high LAP is associated with an increased risk of DR in T2DM patients, and the LAP index appears to be a good predictor of DR risk and severity in patients with T2DM, compared with BMI, WC, and CVAI.Keywords: lipid accumulation product, LAP, Chinese visceral obesity index, CVAI, diabetic retinopathy, DR, abdominal/visceral obesityhttps://www.dovepress.com/association-among-lipid-accumulation-product-chinese-visceral-obesity--peer-reviewed-fulltext-article-DMSOlipid accumulation product (lap)chinese visceral obesity index (cvai)diabetic retinopathy (dr)abdominal/visceral obesity |
| spellingShingle | Li X Li HY Yu ZW Zhang YT Tong XW Gao XY Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study Diabetes, Metabolic Syndrome and Obesity lipid accumulation product (lap) chinese visceral obesity index (cvai) diabetic retinopathy (dr) abdominal/visceral obesity |
| title | Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study |
| title_full | Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study |
| title_fullStr | Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study |
| title_full_unstemmed | Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study |
| title_short | Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study |
| title_sort | association among lipid accumulation product chinese visceral obesity index and diabetic retinopathy in patients with type 2 diabetes a cross sectional study |
| topic | lipid accumulation product (lap) chinese visceral obesity index (cvai) diabetic retinopathy (dr) abdominal/visceral obesity |
| url | https://www.dovepress.com/association-among-lipid-accumulation-product-chinese-visceral-obesity--peer-reviewed-fulltext-article-DMSO |
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