The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study
Background Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. Methods In a nationwide renal biopsy survey including 71,151 native biopsies from 2004 to...
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PeerJ Inc.
2018-03-01
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| Online Access: | https://peerj.com/articles/4522.pdf |
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| author | Diankun Liu Ting Huang Nan Chen Gang Xu Ping Zhang Yang Luo Yongping Wang Tao Lu Long Wang Mengqi Xiong Jian Geng Sheng Nie |
| author_facet | Diankun Liu Ting Huang Nan Chen Gang Xu Ping Zhang Yang Luo Yongping Wang Tao Lu Long Wang Mengqi Xiong Jian Geng Sheng Nie |
| author_sort | Diankun Liu |
| collection | DOAJ |
| description | Background Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. Methods In a nationwide renal biopsy survey including 71,151 native biopsies from 2004 to 2014, diabetic patients were identified according to the clinical diagnosis from referral records. The clinical data were extracted from referral records and pathological reports. Results A total of 1,604 diabetic patients, including 61 patients with T1DM, were analyzed in this study. The median age is 51.39 ± 11.37 years. Male patients accounted for 58% of the population. We found that only 44.7% of diabetic patients had the isolated pathological diagnosis of diabetic nephropathy (DN), while 49.1% had non-diabetic renal disease (NDRD) alone, and 6.2% had NDRD superimposed on DN. Nephrotic syndrome (n = 824, 51.4%) was the most common clinical indication for renal biopsy. Among 887 patients with NDRD, membranous nephropathy (n = 357) was the leading diagnosis, followed by IgA nephropathy (n = 179). Hypertensive renal disease (n = 32), tubulointerstitial nephropathy (n = 27) and acute tubular necrosis (n = 16) accounted for 3.5%, 2.9%, 1.7% of the NDRD cases respectively. Nearly a half (49.2%) of patients with T1DM had NDRD. Discussion Over 55% diabetic patients with kidney disease were diagnosed as non-diabetic renal disease, among which MN and IgAN were the most common two pathological types. |
| first_indexed | 2024-03-09T07:57:29Z |
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| last_indexed | 2024-03-09T07:57:29Z |
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| spelling | doaj.art-57adae2c4b804fc187a575251aafd6bd2023-12-03T00:51:40ZengPeerJ Inc.PeerJ2167-83592018-03-016e452210.7717/peerj.4522The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive studyDiankun Liu0Ting Huang1Nan Chen2Gang Xu3Ping Zhang4Yang Luo5Yongping Wang6Tao Lu7Long Wang8Mengqi Xiong9Jian Geng10Sheng Nie11The National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaThe National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaRuijin Hospital, Shanghai Jiao Tong University, Shanghai, ChinaTongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaSichuan Provincial People’s Hospital, Sichuan Academy of Medical Science, Chengdu, ChinaBeijing Shijitan Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaThe National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaThe National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaThe National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaKing Medical Diagnostics Center, Guangzhou, ChinaThe National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaBackground Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. Methods In a nationwide renal biopsy survey including 71,151 native biopsies from 2004 to 2014, diabetic patients were identified according to the clinical diagnosis from referral records. The clinical data were extracted from referral records and pathological reports. Results A total of 1,604 diabetic patients, including 61 patients with T1DM, were analyzed in this study. The median age is 51.39 ± 11.37 years. Male patients accounted for 58% of the population. We found that only 44.7% of diabetic patients had the isolated pathological diagnosis of diabetic nephropathy (DN), while 49.1% had non-diabetic renal disease (NDRD) alone, and 6.2% had NDRD superimposed on DN. Nephrotic syndrome (n = 824, 51.4%) was the most common clinical indication for renal biopsy. Among 887 patients with NDRD, membranous nephropathy (n = 357) was the leading diagnosis, followed by IgA nephropathy (n = 179). Hypertensive renal disease (n = 32), tubulointerstitial nephropathy (n = 27) and acute tubular necrosis (n = 16) accounted for 3.5%, 2.9%, 1.7% of the NDRD cases respectively. Nearly a half (49.2%) of patients with T1DM had NDRD. Discussion Over 55% diabetic patients with kidney disease were diagnosed as non-diabetic renal disease, among which MN and IgAN were the most common two pathological types.https://peerj.com/articles/4522.pdfRenal biopsyDiabetic nephropathyNon-diabetic renal diseaseDiabetes mellitusMembranous nephropathy |
| spellingShingle | Diankun Liu Ting Huang Nan Chen Gang Xu Ping Zhang Yang Luo Yongping Wang Tao Lu Long Wang Mengqi Xiong Jian Geng Sheng Nie The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study PeerJ Renal biopsy Diabetic nephropathy Non-diabetic renal disease Diabetes mellitus Membranous nephropathy |
| title | The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study |
| title_full | The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study |
| title_fullStr | The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study |
| title_full_unstemmed | The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study |
| title_short | The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study |
| title_sort | modern spectrum of biopsy proven renal disease in chinese diabetic patients a retrospective descriptive study |
| topic | Renal biopsy Diabetic nephropathy Non-diabetic renal disease Diabetes mellitus Membranous nephropathy |
| url | https://peerj.com/articles/4522.pdf |
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