Sub-inhibitory antibiotic treatment selects for enhanced metabolic efficiency

Sub-inhibitory antibiotic treatment selects for enhanced metabolic efficiency

ABSTRACTBacterial growth and metabolic rates are often closely related. However, under antibiotic selection, a paradox in this relationship arises: antibiotic efficacy decreases when bacteria are metabolically dormant, yet antibiotics select for resistant cells that grow fastest during treatment. Th...

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Bibliographic Details
Main Authors: Sai Varun Aduru, Karolina Szenkiel, Anika Rahman, Mehrose Ahmad, Maya Fabozzi, Robert P. Smith, Allison J. Lopatkin
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:Microbiology Spectrum
Subjects:
antibiotic selection
antibiotic resistance
metabolism
bacterial evolution
mathematical modeling
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03241-23

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