Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-κB activation.

Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-κB activation.

Neuroinflammation is involved in the death of retinal ganglion cells (RGCs) after optic nerve injury. The purpose of this study was to determine whether systemic simvastatin can suppress neuroinflammation in the optic nerve and rescue RGCs after the optic nerve is crushed. Simvastatin or its vehicle...

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Bibliographic Details
Main Authors: Seita Morishita, Hidehiro Oku, Taeko Horie, Masahiro Tonari, Teruyo Kida, Akiko Okubo, Tetsuya Sugiyama, Shinji Takai, Hideaki Hara, Tsunehiko Ikeda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3879303?pdf=render

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