A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells

A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells

Per- and polyfluoroalkyl substances (PFAS) have become ubiquitous environmental contaminants that have been associated with adverse pregnancy outcomes in women and experimental research models. Adverse developmental and reproductive outcomes have been investigated for relatively few PFAS, and such s...

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Bibliographic Details
Main Authors: Bevin E. Blake, Brittany P. Rickard, Suzanne E. Fenton
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Toxicology
Subjects:
In Vitro toxicity
trophoblasts
PFAS
high-throughput (HT) testing
alternative methods
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.881347/full

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