Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols.
<h4>Introduction</h4>Recurrent parasitic infections may influence the immune response to vaccines. In the Partnership for Research on Ebola VACcinations extended follow-UP and clinical research capacity build-UP (PREVAC-UP) study being undertaken in Mambolo, northern Sierra Leone, partic...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0270968 |
| _version_ | 1818162285629145088 |
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| author | Frank Baiden Suzanne Fleck Bailah Leigh Philip Ayieko Daniel Tindanbil Tuda Otieno Bolarinde Lawal Mattu Tehtor Maariam Rogers Lazarus Odeny Mary H Hodges Mustapha Sonnie Mohamed Samai David Ishola Brett Lowe Deborah Watson-Jones Brian Greenwood |
| author_facet | Frank Baiden Suzanne Fleck Bailah Leigh Philip Ayieko Daniel Tindanbil Tuda Otieno Bolarinde Lawal Mattu Tehtor Maariam Rogers Lazarus Odeny Mary H Hodges Mustapha Sonnie Mohamed Samai David Ishola Brett Lowe Deborah Watson-Jones Brian Greenwood |
| author_sort | Frank Baiden |
| collection | DOAJ |
| description | <h4>Introduction</h4>Recurrent parasitic infections may influence the immune response to vaccines. In the Partnership for Research on Ebola VACcinations extended follow-UP and clinical research capacity build-UP (PREVAC-UP) study being undertaken in Mambolo, northern Sierra Leone, participants are being followed up to assess the potential impact of exposure to malaria and/or helminth infections on long-term immune response to two Ebola vaccines. To support the development of the assays that will be used in this evaluation, a parasitological survey was conducted in Mambolo between November 2019 and February 2020.<h4>Methods</h4>Healthy individuals aged ≥1 year who were resident in Mambolo Chiefdom were selected using a stratified sampling approach and questionnaires were administered to explore their sociodemographic characteristics. Microscopy was used to detect malaria parasites, intestinal helminths and urinary schistosome infections. Rapid blood tests were used to detect infections with Onchocerca volvulus and Wuchereria bancrofti. We estimated the overall prevalence of these infections and used adjusted logistic regression models to explore risk factors for malaria and hookworm infection.<h4>Results</h4>Eight hundred and fifteen (815) residents, 50.9% of whom were female were surveyed. Overall, 309 (39.1%) of 791 persons tested for malaria had a positive blood slide; Plasmodium falciparum was the dominant species. Helminth infection was detected in 122 (15.0%) of 815 stool samples including three mixed infections. The helminth infections comprised 102 (12.5%) cases of hookworm, 11 (1.3%) cases of Trichuris trichiura, 10 (1.2%) cases of Schistosoma mansoni and two (0.2%) cases of Ascaris lumbricoides. Being male (OR = 2.01, 95% CI 1.15-3.50) and residing in a non-riverine community (OR = 4.02, 95%CI 2.32-6.98) were the factors associated with hookworm infection. Onchocerca volvulus and Wuchereria bancrofti infections were found in 3.3% and 0.4% of participants respectively.<h4>Conclusion</h4>Malaria and hookworm are the most prevalent parasite infections and those most likely to influence long-term immune response to Ebola vaccines among the trial participants. |
| first_indexed | 2024-12-11T16:31:14Z |
| format | Article |
| id | doaj.art-57b213fc2a424c089e9a474c1428a852 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T16:31:14Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-57b213fc2a424c089e9a474c1428a8522022-12-22T00:58:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01177e027096810.1371/journal.pone.0270968Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols.Frank BaidenSuzanne FleckBailah LeighPhilip AyiekoDaniel TindanbilTuda OtienoBolarinde LawalMattu TehtorMaariam RogersLazarus OdenyMary H HodgesMustapha SonnieMohamed SamaiDavid IsholaBrett LoweDeborah Watson-JonesBrian Greenwood<h4>Introduction</h4>Recurrent parasitic infections may influence the immune response to vaccines. In the Partnership for Research on Ebola VACcinations extended follow-UP and clinical research capacity build-UP (PREVAC-UP) study being undertaken in Mambolo, northern Sierra Leone, participants are being followed up to assess the potential impact of exposure to malaria and/or helminth infections on long-term immune response to two Ebola vaccines. To support the development of the assays that will be used in this evaluation, a parasitological survey was conducted in Mambolo between November 2019 and February 2020.<h4>Methods</h4>Healthy individuals aged ≥1 year who were resident in Mambolo Chiefdom were selected using a stratified sampling approach and questionnaires were administered to explore their sociodemographic characteristics. Microscopy was used to detect malaria parasites, intestinal helminths and urinary schistosome infections. Rapid blood tests were used to detect infections with Onchocerca volvulus and Wuchereria bancrofti. We estimated the overall prevalence of these infections and used adjusted logistic regression models to explore risk factors for malaria and hookworm infection.<h4>Results</h4>Eight hundred and fifteen (815) residents, 50.9% of whom were female were surveyed. Overall, 309 (39.1%) of 791 persons tested for malaria had a positive blood slide; Plasmodium falciparum was the dominant species. Helminth infection was detected in 122 (15.0%) of 815 stool samples including three mixed infections. The helminth infections comprised 102 (12.5%) cases of hookworm, 11 (1.3%) cases of Trichuris trichiura, 10 (1.2%) cases of Schistosoma mansoni and two (0.2%) cases of Ascaris lumbricoides. Being male (OR = 2.01, 95% CI 1.15-3.50) and residing in a non-riverine community (OR = 4.02, 95%CI 2.32-6.98) were the factors associated with hookworm infection. Onchocerca volvulus and Wuchereria bancrofti infections were found in 3.3% and 0.4% of participants respectively.<h4>Conclusion</h4>Malaria and hookworm are the most prevalent parasite infections and those most likely to influence long-term immune response to Ebola vaccines among the trial participants.https://doi.org/10.1371/journal.pone.0270968 |
| spellingShingle | Frank Baiden Suzanne Fleck Bailah Leigh Philip Ayieko Daniel Tindanbil Tuda Otieno Bolarinde Lawal Mattu Tehtor Maariam Rogers Lazarus Odeny Mary H Hodges Mustapha Sonnie Mohamed Samai David Ishola Brett Lowe Deborah Watson-Jones Brian Greenwood Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols. PLoS ONE |
| title | Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols. |
| title_full | Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols. |
| title_fullStr | Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols. |
| title_full_unstemmed | Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols. |
| title_short | Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols. |
| title_sort | prevalence of malaria and helminth infections in rural communities in northern sierra leone a baseline study to inform ebola vaccine study protocols |
| url | https://doi.org/10.1371/journal.pone.0270968 |
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