Repeated spontaneous clearance of hepatitis C virus infection in the setting of long-term non-progression of HIV infection
Hepatitis C Virus (HCV) and human immunodeficiency virus (HIV) are global pandemics that affect 170 million and 35 million individuals, respectively. Up to 45% of individuals infected with HCV clear their infections spontaneously – correlating to factors like aboriginal descent and some host specifi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-10-01
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| Series: | Infectious Disease Reports |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/idr/article/view/7142 |
| _version_ | 1818730660557225984 |
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| author | Genevieve Kerkerian Arshia Alimohammadi Tyler Raycraft Brian Conway |
| author_facet | Genevieve Kerkerian Arshia Alimohammadi Tyler Raycraft Brian Conway |
| author_sort | Genevieve Kerkerian |
| collection | DOAJ |
| description | Hepatitis C Virus (HCV) and human immunodeficiency virus (HIV) are global pandemics that affect 170 million and 35 million individuals, respectively. Up to 45% of individuals infected with HCV clear their infections spontaneously – correlating to factors like aboriginal descent and some host specific immune factors. HIV, however, establishes true latency in infected cells and cannot be cured. In the setting of longterm non-progressors (LTNPs) of HIV, a state of immune preservation and low circulating viral load is established. Regarding HIV/HCV co-infection, little is known about the relationship between spontaneous clearance of HCV infection and long-term control of HIV infection without medical intervention. We describe a case of a HIVinfected female defined as a LTNP in whom spontaneous clearance of HCV was documented on multiple occasions. Similar cases should be documented and identified in an effort to develop novel hypotheses about the natural control of these infections and inform research on immune-based interventions to control them. |
| first_indexed | 2024-12-17T23:05:19Z |
| format | Article |
| id | doaj.art-57b2a313d65341cf8f1c88d18f7d4750 |
| institution | Directory Open Access Journal |
| issn | 2036-7430 2036-7449 |
| language | English |
| last_indexed | 2024-12-17T23:05:19Z |
| publishDate | 2017-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Infectious Disease Reports |
| spelling | doaj.art-57b2a313d65341cf8f1c88d18f7d47502022-12-21T21:29:17ZengMDPI AGInfectious Disease Reports2036-74302036-74492017-10-019310.4081/idr.2017.71423788Repeated spontaneous clearance of hepatitis C virus infection in the setting of long-term non-progression of HIV infectionGenevieve Kerkerian0Arshia Alimohammadi1Tyler Raycraft2Brian Conway3Vancouver Infectious Diseases Center; Department of Medicine, University of British Columbia, VancouverVancouver Infectious Diseases CenterVancouver Infectious Diseases CenterVancouver Infectious Diseases CenterHepatitis C Virus (HCV) and human immunodeficiency virus (HIV) are global pandemics that affect 170 million and 35 million individuals, respectively. Up to 45% of individuals infected with HCV clear their infections spontaneously – correlating to factors like aboriginal descent and some host specific immune factors. HIV, however, establishes true latency in infected cells and cannot be cured. In the setting of longterm non-progressors (LTNPs) of HIV, a state of immune preservation and low circulating viral load is established. Regarding HIV/HCV co-infection, little is known about the relationship between spontaneous clearance of HCV infection and long-term control of HIV infection without medical intervention. We describe a case of a HIVinfected female defined as a LTNP in whom spontaneous clearance of HCV was documented on multiple occasions. Similar cases should be documented and identified in an effort to develop novel hypotheses about the natural control of these infections and inform research on immune-based interventions to control them.http://www.pagepress.org/journals/index.php/idr/article/view/7142Hepatitis C, HIV, HCV spontaneous clearance, HIV long-term non-progressor |
| spellingShingle | Genevieve Kerkerian Arshia Alimohammadi Tyler Raycraft Brian Conway Repeated spontaneous clearance of hepatitis C virus infection in the setting of long-term non-progression of HIV infection Infectious Disease Reports Hepatitis C, HIV, HCV spontaneous clearance, HIV long-term non-progressor |
| title | Repeated spontaneous clearance of hepatitis C virus infection in the setting of long-term non-progression of HIV infection |
| title_full | Repeated spontaneous clearance of hepatitis C virus infection in the setting of long-term non-progression of HIV infection |
| title_fullStr | Repeated spontaneous clearance of hepatitis C virus infection in the setting of long-term non-progression of HIV infection |
| title_full_unstemmed | Repeated spontaneous clearance of hepatitis C virus infection in the setting of long-term non-progression of HIV infection |
| title_short | Repeated spontaneous clearance of hepatitis C virus infection in the setting of long-term non-progression of HIV infection |
| title_sort | repeated spontaneous clearance of hepatitis c virus infection in the setting of long term non progression of hiv infection |
| topic | Hepatitis C, HIV, HCV spontaneous clearance, HIV long-term non-progressor |
| url | http://www.pagepress.org/journals/index.php/idr/article/view/7142 |
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