Generative Adversarial Networks in Retinal Image Classification

The recent introduction of generative adversarial networks has demonstrated remarkable capabilities in generating images that are nearly indistinguishable from real ones. Consequently, both the academic and industrial communities have raised concerns about the challenge of differentiating between fa...

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Main Authors: Francesco Mercaldo, Luca Brunese, Fabio Martinelli, Antonella Santone, Mario Cesarelli
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Applied Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3417/13/18/10433
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author Francesco Mercaldo
Luca Brunese
Fabio Martinelli
Antonella Santone
Mario Cesarelli
author_facet Francesco Mercaldo
Luca Brunese
Fabio Martinelli
Antonella Santone
Mario Cesarelli
author_sort Francesco Mercaldo
collection DOAJ
description The recent introduction of generative adversarial networks has demonstrated remarkable capabilities in generating images that are nearly indistinguishable from real ones. Consequently, both the academic and industrial communities have raised concerns about the challenge of differentiating between fake and real images. This issue holds significant importance, as images play a vital role in various domains, including image recognition and bioimaging classification in the biomedical field. In this paper, we present a method to assess the distinguishability of bioimages generated by a generative adversarial network, specifically using a dataset of retina images. Once the images are generated, we train several supervised machine learning models to determine whether these classifiers can effectively discriminate between real and fake retina images. Our experiments utilize a deep convolutional generative adversarial network, a type of generative adversarial network, and demonstrate that the generated images, although visually imperceptible as fakes, are correctly identified by a classifier with an F-Measure greater than 0.95. While the majority of the generated images are accurately recognized as fake, a few of them are not classified as such and are consequently considered real retina images.
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spelling doaj.art-57b43c65b7db42cc84ae9b7c47bff72e2023-11-19T09:27:39ZengMDPI AGApplied Sciences2076-34172023-09-0113181043310.3390/app131810433Generative Adversarial Networks in Retinal Image ClassificationFrancesco Mercaldo0Luca Brunese1Fabio Martinelli2Antonella Santone3Mario Cesarelli4Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, 86100 Campobasso, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, 86100 Campobasso, ItalyInstitute for Informatics and Telematics, National Research Council of Italy, 56124 Pisa, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, 86100 Campobasso, ItalyDepartment of Engineering, University of Sannio, 82100 Benevento, ItalyThe recent introduction of generative adversarial networks has demonstrated remarkable capabilities in generating images that are nearly indistinguishable from real ones. Consequently, both the academic and industrial communities have raised concerns about the challenge of differentiating between fake and real images. This issue holds significant importance, as images play a vital role in various domains, including image recognition and bioimaging classification in the biomedical field. In this paper, we present a method to assess the distinguishability of bioimages generated by a generative adversarial network, specifically using a dataset of retina images. Once the images are generated, we train several supervised machine learning models to determine whether these classifiers can effectively discriminate between real and fake retina images. Our experiments utilize a deep convolutional generative adversarial network, a type of generative adversarial network, and demonstrate that the generated images, although visually imperceptible as fakes, are correctly identified by a classifier with an F-Measure greater than 0.95. While the majority of the generated images are accurately recognized as fake, a few of them are not classified as such and are consequently considered real retina images.https://www.mdpi.com/2076-3417/13/18/10433generative adversarial networkdeep convolutional generative adversarial networkbiomedicalretinamachine learningdeep learning
spellingShingle Francesco Mercaldo
Luca Brunese
Fabio Martinelli
Antonella Santone
Mario Cesarelli
Generative Adversarial Networks in Retinal Image Classification
Applied Sciences
generative adversarial network
deep convolutional generative adversarial network
biomedical
retina
machine learning
deep learning
title Generative Adversarial Networks in Retinal Image Classification
title_full Generative Adversarial Networks in Retinal Image Classification
title_fullStr Generative Adversarial Networks in Retinal Image Classification
title_full_unstemmed Generative Adversarial Networks in Retinal Image Classification
title_short Generative Adversarial Networks in Retinal Image Classification
title_sort generative adversarial networks in retinal image classification
topic generative adversarial network
deep convolutional generative adversarial network
biomedical
retina
machine learning
deep learning
url https://www.mdpi.com/2076-3417/13/18/10433
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AT antonellasantone generativeadversarialnetworksinretinalimageclassification
AT mariocesarelli generativeadversarialnetworksinretinalimageclassification