Polygenic effects on the risk of Alzheimer’s disease in the Japanese population

Polygenic effects on the risk of Alzheimer’s disease in the Japanese population

Abstract Background Polygenic effects have been proposed to account for some disease phenotypes; these effects are calculated as a polygenic risk score (PRS). This score is correlated with Alzheimer’s disease (AD)-related phenotypes, such as biomarker abnormalities and brain atrophy, and is associat...

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Detalhes bibliográficos
Principais autores: Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, the Alzheimer’s Disease Neuroimaging Initiative, the Japanese Alzheimer’s Disease Neuroimaging Initiative
Formato: Artigo
Idioma:English
Publicado em: BMC 2024-02-01
coleção:Alzheimer’s Research & Therapy
Assuntos:
Polygenic risk score
Alzheimer’s disease
Mild cognitive impairment
Acesso em linha:https://doi.org/10.1186/s13195-024-01414-x

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