Ten-year retrospect of the investigation of proximal limbs metastasis in cancer: a multi-center study on survival outcome, limb function status and surgical procedures analysis
Abstract Background The aim of study was to evaluate survival outcome and limb function in cancer patients with proximal limbs metastasis. Associated factors on survival outcome and limb function were identified. The comparative analysis between intramedullary nailing and prosthesis surgery in cance...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11292-5 |
| _version_ | 1797452305200578560 |
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| author | Chao Zhang Jun Wang Haixiao Wu Yile Lin Vladimir P. Chekhonin Karl Peltzer Artem V. Bukharov Andrey D. Kaprin Xu Guo Zheng Liu |
| author_facet | Chao Zhang Jun Wang Haixiao Wu Yile Lin Vladimir P. Chekhonin Karl Peltzer Artem V. Bukharov Andrey D. Kaprin Xu Guo Zheng Liu |
| author_sort | Chao Zhang |
| collection | DOAJ |
| description | Abstract Background The aim of study was to evaluate survival outcome and limb function in cancer patients with proximal limbs metastasis. Associated factors on survival outcome and limb function were identified. The comparative analysis between intramedullary nailing and prosthesis surgery in cancer patients with proximal limb metastasis was performed. Methods In this five-center retrospective study, patients diagnosed with limbs metastasis were collected. Descriptive statistics was used and log-rank test was performed to analyze the survival in subgroups. The Cox proportional hazards regression analysis was performed to identify the independent prognostic factors. The Musculoskeletal Tumor Society (MSTS) scoring system was used to evaluate limb function after surgery, and t test or analysis of variance (ANOVA) was utilized in subgroup analysis. Results A total of 316 patients with limb metastasis were included with mean age at 61.0 years. The most common primary tumor was breast, followed by renal cancer and lung cancer. The median overall survival was 24.0 months and the 1-, 3- and 5-year survival rates were 86.9%, 34.7% and 6.8%, respectively. Primary tumor type, visceral metastasis and chemotherapy were proved to be the independent prognostic factors. The mean Musculoskeletal Tumor Society (MSTS) score was 20.5, significant difference was observed in subgroup of solitary/multiple bone metastasis, with/without pathological fracture, and type of surgery. Conclusion The present study concluded that primary tumor type, visceral metastasis and chemotherapy were three factors affecting the survival of patients. Compared with intramedullary nailing, the patients underwent prosthesis surgery showed better limb function, this procedure should be encouraged in patients with indication. |
| first_indexed | 2024-03-09T15:06:43Z |
| format | Article |
| id | doaj.art-57b503346eb64468b0d067b38a0ccb21 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-09T15:06:43Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-57b503346eb64468b0d067b38a0ccb212023-11-26T13:36:39ZengBMCBMC Cancer1471-24072023-08-0123111210.1186/s12885-023-11292-5Ten-year retrospect of the investigation of proximal limbs metastasis in cancer: a multi-center study on survival outcome, limb function status and surgical procedures analysisChao Zhang0Jun Wang1Haixiao Wu2Yile Lin3Vladimir P. Chekhonin4Karl Peltzer5Artem V. Bukharov6Andrey D. Kaprin7Xu Guo8Zheng Liu9Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for CancerThe Sino-Russian Joint Research Center for Bone Metastasis in Malignant TumorKey Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for CancerThe Sino-Russian Joint Research Center for Bone Metastasis in Malignant TumorThe Sino-Russian Joint Research Center for Bone Metastasis in Malignant TumorThe Sino-Russian Joint Research Center for Bone Metastasis in Malignant TumorP.A. Hertsen Moscow Oncology Research Center - Branch of Federal State Budgetary Institution National Medical Research Radiological Center of the Ministry of Health of the Russian FederationDepartment of Oncology, Radiology and Nuclear Medicine, Medical Institute of Peoples’ Friendship University of RussiaThe Sino-Russian Joint Research Center for Bone Metastasis in Malignant TumorThe Sino-Russian Joint Research Center for Bone Metastasis in Malignant TumorAbstract Background The aim of study was to evaluate survival outcome and limb function in cancer patients with proximal limbs metastasis. Associated factors on survival outcome and limb function were identified. The comparative analysis between intramedullary nailing and prosthesis surgery in cancer patients with proximal limb metastasis was performed. Methods In this five-center retrospective study, patients diagnosed with limbs metastasis were collected. Descriptive statistics was used and log-rank test was performed to analyze the survival in subgroups. The Cox proportional hazards regression analysis was performed to identify the independent prognostic factors. The Musculoskeletal Tumor Society (MSTS) scoring system was used to evaluate limb function after surgery, and t test or analysis of variance (ANOVA) was utilized in subgroup analysis. Results A total of 316 patients with limb metastasis were included with mean age at 61.0 years. The most common primary tumor was breast, followed by renal cancer and lung cancer. The median overall survival was 24.0 months and the 1-, 3- and 5-year survival rates were 86.9%, 34.7% and 6.8%, respectively. Primary tumor type, visceral metastasis and chemotherapy were proved to be the independent prognostic factors. The mean Musculoskeletal Tumor Society (MSTS) score was 20.5, significant difference was observed in subgroup of solitary/multiple bone metastasis, with/without pathological fracture, and type of surgery. Conclusion The present study concluded that primary tumor type, visceral metastasis and chemotherapy were three factors affecting the survival of patients. Compared with intramedullary nailing, the patients underwent prosthesis surgery showed better limb function, this procedure should be encouraged in patients with indication.https://doi.org/10.1186/s12885-023-11292-5Neoplasm MetastasisLimb metastasisPrognosisFunction evaluation |
| spellingShingle | Chao Zhang Jun Wang Haixiao Wu Yile Lin Vladimir P. Chekhonin Karl Peltzer Artem V. Bukharov Andrey D. Kaprin Xu Guo Zheng Liu Ten-year retrospect of the investigation of proximal limbs metastasis in cancer: a multi-center study on survival outcome, limb function status and surgical procedures analysis BMC Cancer Neoplasm Metastasis Limb metastasis Prognosis Function evaluation |
| title | Ten-year retrospect of the investigation of proximal limbs metastasis in cancer: a multi-center study on survival outcome, limb function status and surgical procedures analysis |
| title_full | Ten-year retrospect of the investigation of proximal limbs metastasis in cancer: a multi-center study on survival outcome, limb function status and surgical procedures analysis |
| title_fullStr | Ten-year retrospect of the investigation of proximal limbs metastasis in cancer: a multi-center study on survival outcome, limb function status and surgical procedures analysis |
| title_full_unstemmed | Ten-year retrospect of the investigation of proximal limbs metastasis in cancer: a multi-center study on survival outcome, limb function status and surgical procedures analysis |
| title_short | Ten-year retrospect of the investigation of proximal limbs metastasis in cancer: a multi-center study on survival outcome, limb function status and surgical procedures analysis |
| title_sort | ten year retrospect of the investigation of proximal limbs metastasis in cancer a multi center study on survival outcome limb function status and surgical procedures analysis |
| topic | Neoplasm Metastasis Limb metastasis Prognosis Function evaluation |
| url | https://doi.org/10.1186/s12885-023-11292-5 |
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