Advanced Glycosylation End Products: Effects in Chronic Kidney Disease and Related Disorders
Chronic kidney disease (CKD) is a clinical condition that can end in endstage renal disease (ESRD) and needs dialysis or a kidney transplant. Hypertension, diabetes, obesity, and cardiovascular risk factors are the main contributing factors to the CKD process. One of the factors with exogenous and e...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2023-03-01
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| Series: | International Journal of Nutrition Sciences |
| Subjects: | |
| Online Access: | https://ijns.sums.ac.ir/article_49017_077e5e8a81f9647db1726c9c751d7e57.pdf |
| _version_ | 1811162493187260416 |
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| author | Sara Salahshornezhad Omid Sabet Ghadam Marzieh Akbarzadeh Zahra Sohrabi |
| author_facet | Sara Salahshornezhad Omid Sabet Ghadam Marzieh Akbarzadeh Zahra Sohrabi |
| author_sort | Sara Salahshornezhad |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a clinical condition that can end in endstage renal disease (ESRD) and needs dialysis or a kidney transplant. Hypertension, diabetes, obesity, and cardiovascular risk factors are the main contributing factors to the CKD process. One of the factors with exogenous and endogenous sources affecting the CKD progression or prognosis and its complications is the accumulation of advanced glycosylation end products (AGEs) through the glycosylation of proteins, lipids, or nucleic acids or by dietary sources. AGEs accumulationcan adversely affect the long-term complications of diabetic patient such as nephropathy or retinopathy, especially in those with type 2 diabetes. These compounds can affect cardiovascular health by inducing cardiomyopathy and congestive heart failure. Dialysis patients are among those with higher oxidative stress and lipid peroxidation which can affect the levels of AGEs in these patients. Lower clearance or excretion of the AGEs through kidneys and higher dietary absorption can cause higher levels of AGEs in this population. Higher AGEs are accompanied byhigher rates of CVD, connective tissue disorders, mortality and lower quality of life in CKD patients. Dietary modifications are considered one of the main factors affecting the levels of AGEs in CKD patients which can improve their prognosis and complications even in the absence of diabetes. The ways of cooking and the ingredients focusing on reducing the temperature, cooking time, moist heat, and using acidic ingredients such as lemon juice or using anti-AGE compounds are recommended for reducing AGEs formation in foods. |
| first_indexed | 2024-04-10T06:30:42Z |
| format | Article |
| id | doaj.art-57b70fd3307846eebdb2455ca5cbe59e |
| institution | Directory Open Access Journal |
| issn | 2538-1873 2538-2829 |
| language | English |
| last_indexed | 2024-04-10T06:30:42Z |
| publishDate | 2023-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Nutrition Sciences |
| spelling | doaj.art-57b70fd3307846eebdb2455ca5cbe59e2023-03-01T07:41:49ZengShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18732538-28292023-03-01811810.30476/ijns.2023.97806.122349017Advanced Glycosylation End Products: Effects in Chronic Kidney Disease and Related DisordersSara Salahshornezhad0Omid Sabet Ghadam1Marzieh Akbarzadeh2Zahra Sohrabi3Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranNutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranNutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranChronic kidney disease (CKD) is a clinical condition that can end in endstage renal disease (ESRD) and needs dialysis or a kidney transplant. Hypertension, diabetes, obesity, and cardiovascular risk factors are the main contributing factors to the CKD process. One of the factors with exogenous and endogenous sources affecting the CKD progression or prognosis and its complications is the accumulation of advanced glycosylation end products (AGEs) through the glycosylation of proteins, lipids, or nucleic acids or by dietary sources. AGEs accumulationcan adversely affect the long-term complications of diabetic patient such as nephropathy or retinopathy, especially in those with type 2 diabetes. These compounds can affect cardiovascular health by inducing cardiomyopathy and congestive heart failure. Dialysis patients are among those with higher oxidative stress and lipid peroxidation which can affect the levels of AGEs in these patients. Lower clearance or excretion of the AGEs through kidneys and higher dietary absorption can cause higher levels of AGEs in this population. Higher AGEs are accompanied byhigher rates of CVD, connective tissue disorders, mortality and lower quality of life in CKD patients. Dietary modifications are considered one of the main factors affecting the levels of AGEs in CKD patients which can improve their prognosis and complications even in the absence of diabetes. The ways of cooking and the ingredients focusing on reducing the temperature, cooking time, moist heat, and using acidic ingredients such as lemon juice or using anti-AGE compounds are recommended for reducing AGEs formation in foods.https://ijns.sums.ac.ir/article_49017_077e5e8a81f9647db1726c9c751d7e57.pdfglycosylationrenal failurefood processingcomplications |
| spellingShingle | Sara Salahshornezhad Omid Sabet Ghadam Marzieh Akbarzadeh Zahra Sohrabi Advanced Glycosylation End Products: Effects in Chronic Kidney Disease and Related Disorders International Journal of Nutrition Sciences glycosylation renal failure food processing complications |
| title | Advanced Glycosylation End Products: Effects in Chronic Kidney Disease and Related Disorders |
| title_full | Advanced Glycosylation End Products: Effects in Chronic Kidney Disease and Related Disorders |
| title_fullStr | Advanced Glycosylation End Products: Effects in Chronic Kidney Disease and Related Disorders |
| title_full_unstemmed | Advanced Glycosylation End Products: Effects in Chronic Kidney Disease and Related Disorders |
| title_short | Advanced Glycosylation End Products: Effects in Chronic Kidney Disease and Related Disorders |
| title_sort | advanced glycosylation end products effects in chronic kidney disease and related disorders |
| topic | glycosylation renal failure food processing complications |
| url | https://ijns.sums.ac.ir/article_49017_077e5e8a81f9647db1726c9c751d7e57.pdf |
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