Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19
The severe respiratory effects of the coronavirus disease 2019 (COVID-19) pandemic have necessitated the immediate development of novel treatments. The majority of COVID-19-related fatalities are due to acute respiratory distress syndrome (ARDS). Consequently, this virus causes massive and aberrant...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320424000476 |
| _version_ | 1797203025409867776 |
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| author | Mohsen Ghiasi Peyman Kheirandish Zarandi Abdolreza Dayani Ali Salimi Ehsan Shokri |
| author_facet | Mohsen Ghiasi Peyman Kheirandish Zarandi Abdolreza Dayani Ali Salimi Ehsan Shokri |
| author_sort | Mohsen Ghiasi |
| collection | DOAJ |
| description | The severe respiratory effects of the coronavirus disease 2019 (COVID-19) pandemic have necessitated the immediate development of novel treatments. The majority of COVID-19-related fatalities are due to acute respiratory distress syndrome (ARDS). Consequently, this virus causes massive and aberrant inflammatory conditions, which must be promptly managed. Severe respiratory disorders, notably ARDS and acute lung injury (ALI), may be treated safely and effectively using cell-based treatments, mostly employing mesenchymal stem cells (MSCs). Since the high potential of these cells was identified, a great deal of research has been conducted on their use in regenerative medicine and complementary medicine. Multiple investigations have demonstrated that MSCs and their products, especially exosomes, inhibit inflammation. Exosomes serve a critical function in intercellular communication by transporting molecular cargo from donor cells to receiver cells. MSCs and their derived exosomes (MSCs/MSC-exosomes) may improve lung permeability, microbial and alveolar fluid clearance, and epithelial and endothelial repair, according to recent studies. This review focuses on COVID-19-related ARDS clinical studies involving MSCs/MSC-exosomes. We also investigated the utilization of Nano-delivery strategies for MSCs/MSC-exosomes and anti-inflammatory agents to enhance COVID-19 treatment. |
| first_indexed | 2024-04-24T08:12:46Z |
| format | Article |
| id | doaj.art-57b7bce6374848628926381160243803 |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-04-24T08:12:46Z |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-57b7bce63748486289263811602438032024-04-17T04:49:17ZengElsevierRegenerative Therapy2352-32042024-12-0127319328Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19Mohsen Ghiasi0Peyman Kheirandish Zarandi1Abdolreza Dayani2Ali Salimi3Ehsan Shokri4Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranNanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranDepartment of Nanotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran; Corresponding author.The severe respiratory effects of the coronavirus disease 2019 (COVID-19) pandemic have necessitated the immediate development of novel treatments. The majority of COVID-19-related fatalities are due to acute respiratory distress syndrome (ARDS). Consequently, this virus causes massive and aberrant inflammatory conditions, which must be promptly managed. Severe respiratory disorders, notably ARDS and acute lung injury (ALI), may be treated safely and effectively using cell-based treatments, mostly employing mesenchymal stem cells (MSCs). Since the high potential of these cells was identified, a great deal of research has been conducted on their use in regenerative medicine and complementary medicine. Multiple investigations have demonstrated that MSCs and their products, especially exosomes, inhibit inflammation. Exosomes serve a critical function in intercellular communication by transporting molecular cargo from donor cells to receiver cells. MSCs and their derived exosomes (MSCs/MSC-exosomes) may improve lung permeability, microbial and alveolar fluid clearance, and epithelial and endothelial repair, according to recent studies. This review focuses on COVID-19-related ARDS clinical studies involving MSCs/MSC-exosomes. We also investigated the utilization of Nano-delivery strategies for MSCs/MSC-exosomes and anti-inflammatory agents to enhance COVID-19 treatment.http://www.sciencedirect.com/science/article/pii/S2352320424000476Mesenchymal stem cellsExosomesSARS-CoV-2COVID-19Acute respiratory distress syndromeNanotechnology |
| spellingShingle | Mohsen Ghiasi Peyman Kheirandish Zarandi Abdolreza Dayani Ali Salimi Ehsan Shokri Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19 Regenerative Therapy Mesenchymal stem cells Exosomes SARS-CoV-2 COVID-19 Acute respiratory distress syndrome Nanotechnology |
| title | Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19 |
| title_full | Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19 |
| title_fullStr | Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19 |
| title_full_unstemmed | Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19 |
| title_short | Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19 |
| title_sort | potential therapeutic effects and nano based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by covid 19 |
| topic | Mesenchymal stem cells Exosomes SARS-CoV-2 COVID-19 Acute respiratory distress syndrome Nanotechnology |
| url | http://www.sciencedirect.com/science/article/pii/S2352320424000476 |
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